Progress in molecular studies of Ph-positive and Ph-like acute lymphoblastic leukemia
10.3760/cma.j.issn.1008-1372.2019.10.047
- VernacularTitle: Ph阳性和Ph样急性淋巴细胞白血病的分子学研究进展
- Author:
Yuanyi DING
1
;
Yan LI
;
Rui ZHANG
Author Information
1. Department of Hematology, the First Hospital of China Medical University, Shenyang 110001, China
- Publication Type:Review
- Keywords:
Precursor cell lymphoblastic leukemia-lymphoma;
Philadelphia chromosome;
Biomarkers;
Fusion proteins, bcr-abl;
Review
- From:
Journal of Chinese Physician
2019;21(10):1592-1595
- CountryChina
- Language:Chinese
-
Abstract:
Acute lymphoblastic leukemia (ALL) is a highly heterogeneous disease. The prognosis of adolescents and adults with ALL is worse than that of children with ALL, mainly because of differences in biological characteristics. Molecular markers are of great value on risk stratification, prognosis evaluation, treatment guidance. The good news is with the deepening of studies on pathogenesis of ALL and the introduction of new technologies, novel molecular markers of prognostic relevance continue to be discovered. It was found that increased Sox4 expression was shown to correlate with accelerate leukemia progression. Unfortunately, resistance to medicine is associated with two cyclin-dependent kinase-inhibitor-2AB (CDKN2A/B) deletion.And the deletion of IKZF1 increase risk of relapse. Meanwhile, Ph-like acute lymphoblastic leukemia is characterized by a variety of genetic alterations that activate kinase or cytokine receptor signaling pathway. Identification of these molecular markers will provide important insights into the treatment strategies. This paper reviewed the advance in the Ph-positive ALL and Ph-like ALL.
