Advances in chronic obstructive pulmonary disease-obstructive sleep apnea syndrome

VernacularTitle: 慢性阻塞性肺疾病合并阻塞性呼吸暂停研究进展
Author: Zijie ZHAN ^{1
,

2
,

3} ; Yan CHEN ; Yiming MA ; Yingjiao LONG
Author Information

1. Department of Respiratory and Critical Care Medicine, the Second Xiangya Hospital
2. Research Unit of Respiratory Disease
3. Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha 410011, China
Publication Type:Journal Article
Keywords: Pulmonary disease, chronic obstructive; Sleep apnea, obstructive; Review
From: Journal of Chinese Physician 2019;21(10):1444-1447
CountryChina
Language:Chinese
Abstract: Both chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSA) are common respiratory diseases. Both can exist at the same time, which is referred to as the " overlap syndrome (OS)". Epidemiological studies showed poorer outcomes with increased comorbidities and mortality, which indicated complicated interactions between COPD and OSA. Even though the underlying mechanisms of overlap syndrome have not yet well understood, the airway and systemic inflammation as well as oxidative stress induced by hypoxia played an essential role in the disease interactions and pathogeneses of comorbidities, mainly cardiovascular diseases. One other question is that how to treat the overlap syndrome. This paper summarizes the current research progress of the overlapping interaction and treatment.