Diffusion kurtosis imaging characteristics of brain gray matter nucleus microstructure in Parkinson's disease with different movement disorder subtypes
10.3760/cma.j.issn.1674-6554.2019.10.003
- VernacularTitle: 不同运动障碍亚型帕金森病患者脑灰质核团微观结构的扩散峰度成像特征
- Author:
Bo WANG
1
;
Sha MA
2
;
Xiarong GONG
1
;
Jie ZHANG
1
;
Lixiang REN
1
;
Yuhui CHEN
1
;
Hongfei AN
1
;
Yuejia LUO
3
,
4
Author Information
1. Department of Magnetic Resonane, the First People's Hospital of Yunnan Province(Medical Faculty of Kunming University of Science and Technology), Kunming 650032, China
2. Department of Neurology, the First People's Hospital of Yunnan Province(Medical Faculty of Kunming University of Science and Technology), Kunming 650032, China
3. The Center of Brain Disease and Cognitive Science, Shenzhen University, Shenzhen 518060, China
4. The Research Center of Brain Science and Visual Cognition, Kunming University of Science and Technology, Kunming 650504, China
- Publication Type:Clinical Trail
- Keywords:
Parkinson'
s disease;
Movement disorder subtypes;
Diffusion kurtosis imaging;
Heterogeneity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(10):875-880
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the difference in the microstructure of gray matter nucleus in different movement subtypes of Parkinson’s disease (PD) by diffusion kurtosis imaging (DKI) technique, and to analyze the correlation with clinical manifestations.
Methods:Ninety-seven patients with PD and 83 healthy controls performed conventional MRI sequence and DKI sequence scan. The PD patients were classified into gait disorder subtype (PIGD, n=57) and tremor dominant subtype (TD, n=40)subtypes according to motor symptoms. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), radial diffusivity(Dr), mean kurtosis (MK), axial kurtosis (Ka) and radial kurtosis (Dr) maps and data were generated by software after processing. DKI was performed for all subjects and data was collected from different brain regions in both hemispheres, including red nucleus(RN), substantia nigra pars reticulate(SNr), substantia nigra pars compacta(SNc), putamen(PUT), globus pallidus(GP), head of caudate nucleus (CN)and thalamus(THA).
Results:TD showed a higher MMSE score(P=0.019), but lower modified Hoehn-Yahr score than that in PIGD (P<0.001), there was no significant difference of age of onset, sex, limbs of onset or disease duration between two PD subgroups. Compared with healthy controls, both TD and PIGD showed down-regulated MD, Da and Dr and up-regulated Ka values(P<0.001); MK(0.83±0.26, 0.80±0.18) was increased in SNr both in TD and PIGD, while SNc, PUT and GP (0.84±0.20, 0.75±0.07, 0.81±0.14)were decreased only in TD (P=0.017, P=0.010, P=0.020, P<0.001, P=0.002). The Kr values of PUT and CN(0.71±0.17, 0.72±0.14) were reduced in PIGD, while CN(0.70±0.14) were reduced in TD respectively (P=0.002, P=0.031, P=0.007). The MK was lower in TD than that in PIGD (t=-2.214, P=0.029), and no significant difference was found in other grey matter nuclei between TD and PIGD(P>0.05). Moreover, there was no significant correlation between DKI value and disease duration, MMSE score or Hoehn-Yahr scale (P>0.05) in TD and PIGD.
Conclusion:There is heterogeneity of clinical symptoms between these two subgroups of PD. DKI can quantify the microstructural changes of grey matter nucleus in different type PD patient.
