Analysis of the vascular risk factors for the elderly with mild cognitive impairment in community
10.3760/cma.j.issn.1674-6554.2019.10.001
- VernacularTitle: 社区老年人轻度认知功能损害的血管危险因素分析
- Author:
Pei SUN
1
;
Changjiang LUO
2
;
Qingqing GENG
2
;
Qian ZHANG
2
;
Shuangshuang CHEN
2
;
Wendi WANG
1
;
Xiang WANG
1
;
Yifeng DU
1
;
Chuanqiang QU
1
Author Information
1. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China
2. Department of Neurology, Jinan Shizhong People’s Hospital, Jinan 250002, China
- Publication Type:Clinical Trail
- Keywords:
Cognitive impairment;
Vascular risk factors;
Hypertension;
Elderly
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2019;28(10):865-869
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effects of vascular risk factors on cognitive function among the elderly in community.
Methods:A cross-sectional study was conducted in 1 269 elderly people (aged 65 and over) who were randomly selected from three communities.Through face-to-face interview, cognitive function was assessed by mini-mental state examination(MMSE), and blood samples were collected for laboratory examination.Logistic regression analysis was used to analyze the vascular risk factors affecting cognitive function.
Results:Age ((73.1±6.6), (71.3±4.9), t=4.603, P<0.05), education level (χ2=12.727, P<0.05), hypertension (χ2=9.106, P<0.05) and LDL-C (χ2=5.157, P<0.05) were significantly different in the elderly with or without mild cognitive impairment(MCI). After controlling age, gender and education, the logistic regression analysis showed that hypertension(β=0.378, P=0.006, OR(95%CI)=1.44(1.10-1.91)), systolic blood pressure ≥140 mmHg(β=0.350, P=0.011, OR(95%CI)=1.42(1.08-1.86), 1 mmHg=0.133 kPa), and high LDL-C(β=0.355, P=0.014, OR(95%CI)=1.43(1.08-1.89)) were the risk factors of MCI in the elderly in the community.Hypertension alone or high LDL-C (β=0.365, P=0.029, OR(95%CI)=1.44(1.04-2.00)) alone was risk factor for mild cognitive impairment in the elderly in the community.The risk of mild cognitive impairment in the elderly with hypertension and high LDL-C was 2.00 times higher than that in the healthy elderly (β=0.696, P<0.05, OR(95%CI)=2.00(1.36-2.97)).
Conclusion:Mild cognitive impairment in the elderly is closely related to hypertension and elevated LDL-C levels.Multiple vascular risk factors can further increase the risk of cognitive impairment.
