Fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation
10.3760/cma.j.issn.0253-2727.2019.10.011
- VernacularTitle: 粪菌移植治疗异基因造血干细胞移植后难治性腹泻四例报告并文献复习
- Author:
Qian WANG
1
;
Yuewen FU
;
Yongqi WANG
;
Hao AI
;
Fangfang YUAN
;
Xudong WEI
;
Yongping SONG
Author Information
1. Department of Hematology, The Anti- Cancer Hospital Affiliated with Zhengzhou University, Zhengzhou 450008, China
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Diarrhea;
Graft versus host disease;
Fecal microbiota transplantation
- From:
Chinese Journal of Hematology
2019;40(10):853-855
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the availability and safety of fecal microbiota transplantation for patients with refractory diarrhea after allogeneic hematopoietic stem cell transplantation (allo-HSCT) .
Methods:Four acute leukemia patients suffered from refractory diarrhea after allo-HSCT. One of them was refractory intestinal infection, the others were intestinal graft versus host disease. One or two doses of fecal microbiota, 3.4-6.0 U for one dose, were infused via nasal-jejunal tube. The curative effect and side effects were reviewed.
Results:Three cases achieved complete remission while 1 was stable disease. The side effects included fever, abdominal pain and diarrhea, which all were Ⅰ grade.
Conclusion:Fecal microbiota transplantation was effective and safe for refractory diarrhea after allo-HSCT.
