Research progress of lipolipomics in primary hepatocellular carcinoma
10.3760/cma.j.issn.1007-3418.2019.10.015
- VernacularTitle: 脂质组学在原发性肝癌中的研究进展
- Author:
Xiaoju SHI
1
;
Qianqian ZHENG
2
;
Junqi NIU
1
;
Guoyue LYU
1
;
Xingkai LIU
1
;
Guangyi WANG
1
Author Information
1. Hepatobiliary Pancreatic Department, The First Hospital of Jilin University, Changchun 130021, China
2. Department of Pathophysiology, China Medical University, Shenyang 110122, China
- Publication Type:Review
- Keywords:
Hepatocellular carcinoma;
Lipidomics;
Nonalcoholic fatty liver disease
- From:
Chinese Journal of Hepatology
2019;27(10):809-812
- CountryChina
- Language:Chinese
-
Abstract:
Presently, nonalcoholic fatty liver disease has become the most common pathogenic factor of chronic liver disease worldwide that can lead to the occurrence of hepatocellular carcinoma (HCC). Lipid metabolism in cancer cells is closely related to tumorgenesis, invasion and metastasis, and thus acts as one of the hallmark of cancer cells. Lipolipomics is an important branch of metabolomics, which has been adapted recently in the study of HCC for analysis of the structure and function of lipid components by chromatography and mass spectrometry. Fatty acids, glycerides, glycerophospholipids, sphingolipids, and sterol are significantly different in HCC tissues or serum. Therefore, it contributes to the diagnosis, determination of prognosis, mechanistic study and targeted therapy of HCC.
