Relationship between liver controlled attenuation parameters and body fat mass and its distribution
10.3760/cma.j.issn.1007-3418.2019.10.004
- VernacularTitle: 肝脏受控衰减参数与人体脂肪质量和其分布的关系
- Author:
Youlin SHAO
1
;
Suocai ZHANG
1
;
Jianming WU
1
;
Fengcai GUO
1
;
Longgen LIU
1
;
Chunyan YE
1
;
Tong YAN
1
;
Qi CAO
1
;
Fan ZHANG
2
;
Jing WANG
3
;
Yonghua MAO
4
;
Jiangao FAN
5
Author Information
1. Department of Hepatology and Center of Fatty Liver, Changzhou Third People's Hospital, Changzhou 213001, China
2. Department of Endocrinology and Center of Fatty Liver, Changzhou Third People's Hospital, Changzhou 213001, China
3. Department of Cardiology and Center of Fatty Liver, Changzhou Third People's Hospital, Changzhou 213001, China
4. Department of Nutrition and Center of Fatty Liver, Changzhou Third People's Hospital, Changzhou 213001, China
5. Department of Gastroenterology and Center of Fatty Liver, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
- Publication Type:Journal Article
- Keywords:
Fatty liver;
Controlled attenuation parameters;
Body fat mass
- From:
Chinese Journal of Hepatology
2019;27(10):754-759
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between liver controlled attenuation parameters (CAP) and body fat mass and its distribution.
Methods:From May to December 2018, 978 adult patients visited at the fatty liver center of the Third People's Hospital of Changzhou were treated. The patient's liver controlled attenuation parameters were measured by transient elastography and the body fat mass and its distribution were measured by bioelectrical impedance technology. Pearson’s correlation coefficient was adopted to describe the correlation between liver CAP value and body mass index (BMI), body fat mass index (BFMI), trunk fat mass index (TFMI), limbs fat mass index (LFMI) and visceral fat area (VFA). Receiver operating characteristic curve (ROC) and area under the curve (AUC) were used to evaluate BMI, BFMI, TFMI, LFMI and VFA to differentiate the cut-off points and efficacy of CAP for diagnosing grading of fatty liver changes in S0-1 and S2-3.
Results:In 653 cases of male, S0 ~ S3 accounted for 4.90%, 3.37%, 22.36% and 69.37%, respectively, and in 325 cases of females, S0 ~ S3 accounted for 7.38%, 6.46%, 13.23% and 72.92%, respectively. Female patients had more visceral, trunk and limbs fat than male (P < 0.01). Body mass, body fat mass, body fat percentage, BMI, BFMI, TFMI, LFMI, and VFA were increased in male and female patients with increasing liver fat grade (P < 0.01). CAP values of male and female patients were positively correlated with BMI, BFMI, TFMI, LFMI and VFA. Percentage of body fat mass increased with increasing liver fat grade (male: F = 13.42, P < 0.001; female: F = 3.22, P = 0.023); while limb fat mass percentage did not increase with liver fat grade (Male: F = 1.13, P = 0.34; female: F = 1.05, P = 0.37). Hepatic steatosis grading (S0 ~ 1 or S2 ~ 3) diagnosed with CAP were distinguished through BMI, BFMI, TFMI, LFMI and VFA. AUC was 0.80 ~ 0.82 in males (P < 0.01), and 0.75 ~ 0.78 in females (P < 0.01).
Conclusion:The liver CAP value is positively correlated with the body's limbs, trunk and visceral fat, and has a strong correlation with trunk and visceral fat. BMI, BFMI, TFMI, LFMI and VFA up to some extent can identify the CAP diagnosis of grading of fatty liver changes in S0-1 and S2-3.
