The progress of hepatocellular adenoma malignant transforming in molecule mechanism researches
10.3760/cma.j.issn.1007-8118.2019.10.021
- VernacularTitle: 肝细胞腺瘤癌变分子机制的研究进展
- Author:
Shuo ZHOU
1
;
Shugeng ZHANG
2
;
Ruipeng SONG
2
;
Lianxin LIU
1
Author Information
1. Department of Liver Surgery, First Affiliated Hospital of Harbin Medical University, Harbin 150000, China
2. Department of General Surgery in Southern Hospital, First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230000, China
- Publication Type:Review
- Keywords:
Adenoma, liver cell;
Mechanism;
Genes, TERT;
β
-catenin
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(10):794-796
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular adenoma is a rare type of benign tumor in the liver. It has high risk of rupture and low risk of malignant transform. Recently the incidence of hepatocellular adenoma malignant transforming has been increasing. The malignant progress of hepatocellular adenoma develop to hepatocellular carcinoma has the transition state. This course not only relyes on the CTNNB1 gene exon 3 mutations, but also depends on TERT gene promoter mutation. This article will elaborate the hepatocellular adenoma malignant transforming in molecule mechanism, pathological diagnosis and therapies.
