Dual roles of immune cells and cytokines in hepatic ischemia reperfusion injury
10.3760/cma.j.issn.1007-8118.2019.10.019
- VernacularTitle: 免疫细胞和细胞因子在肝脏缺血再灌注损伤中的双重作用
- Author:
Hongqiang ZHAO
1
;
Haorun LIU
;
Jiyong SONG
;
Weimin LI
Author Information
1. Department of Hepatobiliary Surgery, the Eighth Medical Centre, Chinese PLA General Hospital, Beijing 100091, China
- Publication Type:Review
- Keywords:
Reperfusion injury;
Liver;
Cytokines;
High mobility group protein B1;
Dendritic cells
- From:
Chinese Journal of Hepatobiliary Surgery
2019;25(10):786-788
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia-reperfusion injury is one of the main causes of complications related to liver transplantation, hepatectomy, trauma and hemorrhagic shock. The cells of ischemia and hypoxic injury release of injury-related molecular patterns, lead to the activation of immune cells and cytokine, which further aggravates the inflammatory response and enlarges the injury. It’s indicated that injury-related molecular patterns, liver resident immune cells and cytokines play a key role in promoting inflammation and liver ischemia-reperfusion injury. However, recent studies suggested that the ischemia cells and cytokines played acomplex role in this process. Relevant progresses were reviewed in this article.
