Advances of chronic tympanic membrane perforation animal model
10.3760/cma.j.issn.1673-0860.2019.10.015
- VernacularTitle: 长期鼓膜穿孔动物模型的研究进展
- Author:
Xingmei WEI
1
;
Guodong FENG
1
;
Zhiqiang GAO
1
Author Information
1. Department of Otorhinolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
- Publication Type:Review
- Keywords:
Tympanic membrane perforation;
Models, animal
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2019;54(10):781-786
- CountryChina
- Language:Chinese
-
Abstract:
Chronic tympanic membrane perforation in an animal model has been widely used. The ideal model is a lasting and stable perforation without infection. For half a century, several physical modalities have been evolved, such as thermal injury, infolding technique, tympanostomy tube, re-myringotomy, and laser myringotomy. Chemical methods using chemical substance inhibiting growth and repair of cells as well as using gene defect animals are also applied. We have found the success rate is lower when using only one method and it would be better to combine physical and chemical approaches. In this article, we review the research advances in the establishment of chronic tympanic membrane perforation animal model.
