Advances in the study of Parkinson′s tremor
10.3760/cma.j.issn.1006-7876.2019.10.013
- VernacularTitle: 帕金森病震颤研究进展
- Author:
Si YAN
1
;
Ziyu WANG
;
Wei HUANG
Author Information
1. Department of Neurology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China
- Publication Type:Review
- Keywords:
Parkinson disease;
Tremor;
Diagnosis;
Treatment outcome
- From:
Chinese Journal of Neurology
2019;52(10):861-865
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson′s disease is a neurodegenerative disease with early prominent death of dopaminergic neurons in the substantia nigra pars compacta. The resultant dopamine deficiency within the basal ganglia leads to a movement disorder characterized by classical parkinsonian motor symptoms. At present, the mechanism of Parkinson′s disease tremor has not been fully elucidated, and there are different hypotheses. Based on Duval′s hypothesis of "finger-switch-dimmer" on the pathogenesis of tremor in Parkinson′s disease, and combined with clinical practice, this review comprehensively expounds how tremor in Parkinson′s disease is generated under this model, and introduces the classification, diagnosis and treatment of tremor in Parkinson′s disease, so as to provide new ideas for the treatment of tremor in Parkinson′s disease in the future.
