Histopathological Observation of Fixed Drug Eruption.
- Author:
Won Yong KIM
;
Jong Bae HAN
;
Dong Heon SEO
;
Kwang Soo KIM
;
Sook Ja SON
- Publication Type:Original Article
- MeSH:
Biopsy;
Cytoplasm;
Dermatology;
Dermis;
Drug Eruptions*;
Eosinophils;
Epidermis;
Humans;
Keratinocytes;
Melanins;
Skin
- From:Korean Journal of Dermatology
1985;23(1):14-17
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Thirty-nine patients with fixed drug eruption who visited the Department of Dermatology in National Medical Center from January 1g7g to December 1982 were selected. Among them, twentyseven patients performed skin biopsy and were evaluated histopathologically on the basis of duration. The results were as follows; ].In the early stage less than 1 week of duration, hydropic degeneration of basal cells, necrotic keratinocytes with eosinophilic cytoplasm and pknotic nucleus in the epidermis, and mixed cell infiltration with eosinophlis in the upper dermis were prominently. In the late stage more than 20 days of duration, acanthosis, an increased amount of melanin in the basal cell layer and presence of melanophages were found more prominent, however, hydropic degeneration of basal cells, papillary dermal ederna, inflammatory infiltration of mononuclear cells were found less prounced or absent.
