Association between TNFRSF11A and TNFRSF11B gene polymorphisms and the outcome of hepatitis C virus infection
10.3760/cma.j.issn.0254-6450.2019.10.022
- VernacularTitle: TNFRSF11A和TNFRSF11B基因多态性与HCV感染转归的关系
- Author:
Jingjing WU
1
;
Peng HUANG
1
;
Ming YUE
2
;
Chunhui WANG
3
;
Chao WU
4
;
Jianguo SHAO
5
;
Hong XUE
6
;
Zuqiang FU
1
;
Lingyun ZHUO
1
;
Rongbin YU
1
;
Yun ZHANG
1
,
7
Author Information
1. Key Laboratory of Infectious Diseases, Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
2. Department of Infectious Diseases, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
3. Eastern Theater Command Center for Disease Prevention and Control, Nanjing 210002, China
4. Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China
5. Department of Gastroenterology, The Third People’s Hospital of Nantong Affiliated to Nantong University, Nantong 226001, China
6. Fourth Ward, The Third People’s Hospital of Nantong Affiliated to Nantong University, Nantong 226001, China
7. Eastern Theater Command Center for Disease Prevention and Control, Nanjing 210002, China
- Publication Type:Clinical Trail
- Keywords:
Hepatitis C virus;
Gene polymorphism;
Tumor necrosis factor receptor superfamily members 11A;
Tumor necrosis factor receptor superfamily members 11B
- From:
Chinese Journal of Epidemiology
2019;40(10):1291-1295
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the tumor necrosis factor receptor superfamily members 11A (TNFRSF11A) and 11B (TNFRSF11B) gene polymorphisms and the outcome of hepatitis C virus (HCV) infection.
Methods:In this case-control study, 749 cases of persistent HCV infection, 494 cases of spontaneous clearance and 1 486 control subjects were included from 2008 to 2016. TaqMan-MGB probe method was used to detect the genotype of TNFRSF11A rs1805034 and TNFRSF11B rs2073617. The genotypes distribution of the two single nucleotide polymorphisms (SNP) were analyzed in different populations.
Results:Co-dominant model showed that individuals carrying the rs2073617 CC genotype were prone to have chronic HCV infection, compared with individuals carrying the rs2073617 TT genotype (OR=1.517, 95%CI: 1.055-2.181, P=0.024). Recessive model results showed that individuals carrying rs2073617 CC genotype were more likely to develop chronic HCV infection compared with individuals carrying rs2073617 TT or TC genotype (OR=1.435, 95%CI: 1.033-1.996, P=0.032). Additive model showed that the risk for chronic HCV infection increased with the increase of the number of rs2073617 C alleles (OR=1.204, 95%CI: 1.013-1.431, P=0.035).
Conclusion:The genetic polymorphism of TNFRSF11B rs2073617 might be related with the chronicity of HCV infection.
