Hematologic Effect of Minute Treatment of Oral Thiamphenicol in Male Gonorrhea.
- Author:
Won Yong KIM
;
Joong Hwan KIM
- Publication Type:Original Article
- MeSH:
Anemia, Aplastic;
Gonorrhea*;
Hematocrit;
Hematopoietic System;
Humans;
Male*;
Reference Values;
Reticulocytes;
Thiamphenicol*
- From:Korean Journal of Dermatology
1985;23(1):33-38
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The effect of thiamphenicol on hematopoietic system has to be evaluated. One hundred and fifteen male patients had been given oral 2. 5 gm thiamphenicol for uncomplicated gonococcal infection. ln this study, hemoglobin, WBC, hematocrit, reticulocyte and differential WBC counts were evaluated before, R days, 10 days and 1 month after the treatment. Hemoglobin, WBC, reticulocyte and differential WRC counts did not show any differences between pre and 3 days, l0days and 1 month post-treatment. In jailed cases, WBC count was found to be raiseri pretreatment(7,500 1-1.700, n='30) and 3 days after the treatment(v, 1pp+1,6p0, n=Rp) from normal value (Ii,100.:>1,600 in NMC biochemistry). In cured cases, WBC count was also found to be raised pre-treatment(7,50Q-i- 2,100, n=54) from normal value(6, 1001, 500), but returned to norrna1 3 days (6, 100 ! 1, 500, n = 54) and 10 days after the treatment, no cases showed any significant changes for WBC count(v,ppp-+1,gpp, n=7) from normal value(6,1%)- 1,500). Other side effect of thiamphenicol, such as hematologic toxicity and aplastic anemia had not been observed. Therefore, thiamphenicol 2. 5 gm p.o. is well tolerated and non-toxic treatment.
