New research progress of microRNAs in breast cancer
10.3760/cma.j.issn.1009-9158.2019.10.014
- VernacularTitle: MicroRNA在乳腺癌研究中的新进展
- Author:
Fan YI
1
;
Zhaoqiong ZENG
1
;
Changjuan DENG
1
;
Ping LI
2
;
Xiaobing XIE
2
Author Information
1. Hunan University of Chinese Medicine, Changsha 410208, China
2. Center for Medical Laboratory and Pathology, the First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
- Publication Type:Review
- Keywords:
MiRNA;
Breast cancer;
Diagnostic marker;
Target treatment
- From:
Chinese Journal of Laboratory Medicine
2019;42(10):884-889
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are non-coding single-stranded RNA molecules whose role in breast cancer has been gradually discovered and clinically recognized and valued. MiRNAs play a role in the regulation of related target genes and signaling pathways in breast cancer, and participate in the proliferation, apoptosis, invasion and metastasis of breast cancer cells, and have new biomarker potential in clinical diagnosis and prognosis of breast cancer. It provides new ways and methods for the clinical treatment of breast cancer, and has important value and application prospects in reducing drug resistance and enhancing drug sensitivity. This article reviews the research progress of miRNAs in the molecular mechanism, clinical diagnosis, prognosis and clinical target treatment of breast cancer, and puts some suggestions and forward for future research directions.
