Opportunities and challenges for nanopore-based clinical diagnostics
10.3760/cma.j.issn.1009-8158.2019.10.003
- VernacularTitle: 纳米孔道检测新技术临床检验医学应用的机遇和挑战
- Author:
Changjian ZHAO
1
;
Binwu YING
1
;
Jia GENG
1
Author Information
1. Department of Laboratory Medicine, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
- Publication Type:Journal Article
- Keywords:
Microfluidics;
Nanopores;
Sequence analysis;
Whole genome sequencing;
Molecular diagnostic techniques
- From:
Chinese Journal of Laboratory Medicine
2019;42(10):827-830
- CountryChina
- Language:Chinese
-
Abstract:
The detection technology based on micro-nanofluidics has been developed fast with wide applications in biochemical analysis and clinical diagnostics because of its small sample volume requirement, rapid detection and portability. Recently, nanofluidics emerges for DNA sequencing and biomarker detection. With nanopore technology,whole genome sequence in 24 hours with a cost of lower than $1000 could be realized. However, improvement in the detection accuracy and repeatability are still desired for clinic diagnostics. Nanopore technology could be powerful tools for clinical diagnostics, providing new opportunities for laboratory medicine.
