Correlation between preoperative controlling nutritional status (CONUT) score and adjuvant chemotherapy in stage Ⅱ-Ⅲ gastric cancer after curative resection
10.3760/cma.j.issn.1007-631X.2019.10.008
- VernacularTitle: 术前控制营养状况评分与根治性切除术加辅助化疗胃癌患者预后的关系
- Author:
Guisheng XIE
1
;
Haotang WEI
1
;
Feng CHEN
1
;
Min NI
1
;
Shunhui GAO
1
;
Feng CHEN
1
Author Information
1. Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, 530031, China
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Nutrition assessment;
Prognosis
- From:
Chinese Journal of General Surgery
2019;34(10):850-854
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To elucidate the prognostic impact of preoperative control of nutritional status (CONUT) scores on gastric cancer patients undergoing adjuvant chemotherapy after radical gastrectomy.
Methods:A retrospective analysis of 536 stage Ⅱ-Ⅲ gastric cancer patients undergoing adjuvant chemotherapy after radical resection from Jul 1998 to Dec 2014 was performed. Patients were divided into high (≥3) and low (≤2) CONUT groups with a CONUT score of 3 divided into critical values.
Results:The 5-year survival rate of the high CONUT group was significantly lower than that of the low CONUT group (37.3 % vs. 55.7%, P<0.001). Univariate analysis showed that the high CONUT group was associated with larger tumors, more lymph node metastasis, lower body mass index, higher prognostic nutritional index, and preoperative anemia (all P<0.05). Multivariate analysis showed that the CONUT score was an independent prognostic factor for patients with gastric cancer (HR: 1.564, 95% CI: 1.090-2.321, P=0.016). The 5-year survival rate of the high CONUT group was significantly lower than that of the low CONUT group (P<0.05).
Conclusion:The CONUT score is an indicator for predicting the prognosis of patients with stage Ⅱ-Ⅲ gastric cancer after adjuvant chemotherapy. The nutritional evaluation is helpful to develop a plan for preoperative nutritional intervention.
