Preoperative platelet-to-lymphocyte count ratio predicts peritoneal metastasis in patients with advanced gastric cancer
10.3760/cma.j.issn.1007-631X.2019.10.002
- VernacularTitle: 术前血小板与淋巴细胞计数比值预测进展期胃癌腹膜转移
- Author:
Wenyang PANG
1
;
Wenjing CHEN
2
;
Guanbao ZHU
2
;
Changyuan HU
2
;
Yiqi CAI
2
Author Information
1. Department of Surgical Oncology, Taizhou Municipal Hospital, Taizhou 318000, China
2. Department of General Surgery, the First Affiliated Hospital , Wenzhou Medical University, Wenzhou 325035, China
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Platelet;
Lymphocyte;
Neoplasm metastasis
- From:
Chinese Journal of General Surgery
2019;34(10):828-832
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the predictive value of the platelet-to-lymphocyte ratio(PLR), neutrophil-to-lymphocyte ratio(NLR)and tumor-related factors on the peritoneal metastasis in advanced gastric cancer patients.
Methods:A total of 701 pathologically confirmed gastric cancer patients who underwent surgery at the First Affiliated Hospital of Wenzhou Medical University between Jan 2009 and Jan 2012 were enrolled.
Results:Univariate analysis indicated that tumor location, tumor size, serosal invasion, depth of invasion, pathological type, lymph node metastasis and PLR were related to peritoneal metastasis(all P<0.05). According to the area under the ROC curve, the optimal cutoff value of PLR for predicting peritoneal metastasis was 132.43 (sensitivity 71.8%, specificity 50.6%). There were significant differences in tumor size, TNM stage, lymph node metastasis and serosal infiltration between high PLR group and low PLR group. Multivariate Logistic analyses revealed that PLR (HR=2.205, P=0.003), lymph node metastasis(HR=3.113, P=0.010)and tumor size(HR=1.150, P=0.014) were independent risk factors for peritoneal metesfasis.
Conclusions:Preoperative PLR is valuable in predicting peritoneal metastasis of advanced gastric cancer and it is an independent risk factor for peritoneal metastasis of gastric cancer.
