The application of whole-brain radiotherapy for non-small cell lung cancer with brain metastases: evolution and revolution

VernacularTitle: 非小细胞肺癌脑转移全脑放疗应用的变革及发展
Author: Siran YANG ¹ ; Jianping XIAO
Author Information

1. Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing 100021, China
Publication Type:Review
Keywords: Brain metastasis, lung neoplasms/whole brain radiotherapy; Neurocognitive function; Quality of life
From: Chinese Journal of Radiation Oncology 2019;28(10):784-787
CountryChina
Language:Chinese
Abstract: Whole brain radiotherapy (WBRT) was widely used clinically as the standard therapy for brain metastases (BM). With the development of radiotherapy technology and systemic therapies, the non-small cell lung cancer (NSCLC) patients have prolonged local control rate and median survival time, meanwhile post-radiotherapy intracranial toxicities often lead to serious impacts on the quality of life and neurocognitive function. Therefore, the role WBRT played should have been reevaluated. The purpose of this review is to analyze the clinical application value of WBRT in the context of new treatments for NSCLC with BM, and to predict the main developing directions of WBRT in the future.