Early assessment of treatment response during radiotherapy for esophageal cancer based on CT radiomics analysis
10.3760/cma.j.issn.1004-4221.2019.10.003
- VernacularTitle: 基于诊断CT影像组学对食管癌放疗疗效早期评估
- Author:
Dingjie LI
1
;
Hui WU
;
Ru LIU
;
Yougai ZHANG
;
Wei GUO
;
Zhaoyang LOU
;
Hong GE
Author Information
1. Department of Radiation Oncology, Henan Cancer Hospital, Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China
- Publication Type:Journal Article
- Keywords:
Radiomics;
Early assessment;
Esophageal neoplasm/radiotherapy
- From:
Chinese Journal of Radiation Oncology
2019;28(10):731-734
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the feasibility of assessing the treatment response using diagnostic-quality CT imaging features during radiotherapy for esophageal cancer.
Methods:Thirty-three patients with stage Ⅰ to IV esophageal cancer undergoing intensity-modulated radiotherapy were recruited in this study. CT images were acquired using a CT-on-rail imaging system. Imaging data of CT images including gross tumor volume (GTV), the volume of spinal cord and non-irradiated tissue (NIT), CT mean (MCTN), standard deviation , and skewness were collected and analyzed by using MIM image processing system. Patients were divided into the effective group (complete remission and partial remission, n=24) and ineffective group (no change and progression, n=9) based on the outcomes of 3-month follow-up. The imaging data were statistically compared between two groups using the self-designed Matlab software.
Results:The tumor volume and MCTN of 33 patients were gradually decreased with the increase of radiotherapy dose. The tumor volume and MCTN were decreased by 42.46% and 5.76 HU in the effective group, more significant compared with 21.76% and 3.66 HU in the ineffective group (both P<0.005). The skewness in the ineffective group was decreased by 0.503 with the increasing radiation dose, whereas that in the effective group was increased by -0.450(P=0.034). Spinal cord and NIT did not significantly change with the increasing radiation dose.
Conclusion:Analysis of the characteristic data of CT images of patients with esophageal cancer during radiotherapy may early predict the clinical efficacy of radiotherapy.
