A preliminary study on prediction efficacy of multimodal MRI-based radiomics in combination with random forest model for preoperative glioma IDH1 gene type expression
10.3760/cma.j.issn.1005-1201.2019.10.014
- VernacularTitle: 多模态MRI影像组学随机森林模型预测术前大脑胶质瘤IDH1基因表达类型效能的初步探讨
- Author:
Wenting LAN
1
;
Zhan FENG
2
;
Yan ZHANG
3
;
Zhenya ZHAO
1
;
Yi HUANG
4
;
Qiuli HUANG
1
;
Yuning PAN
1
Author Information
1. Department of Radiology, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315040, China
2. Department of Radiology, the First Affiliated Hospital of Medical College Zhejiang University, Hangzhou 310006, China
3. Department of Radiology, Lihuili Hospital, Ningbo Medical Center, Ningbo 315040, China
4. Department of Neurosurgery, Ningbo First Hospital, Ningbo Hospital of Zhejiang University, Ningbo 315040, China
- Publication Type:Journal Article
- Keywords:
Glioma;
Texture;
Radiomics;
Magnetic resonance imaging
- From:
Chinese Journal of Radiology
2019;53(10):864-870
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To preliminarily analyze the prediction efficiency of multimodal MRI-based radiomics model for preoperative glioma IDH1 gene expression type.
Methods:The MRI data of 108 surgery-proven glioma patients from May 2015 to January 2019 were retrospectively analyzed, and the MRI data included axial T1WI,T2WI,fluid attenuated inversion recovery (FLAIR),DWI imaging and enhanced T1WI sequence.Forty-seven cases were IDH1 mutant type, and 61 cases were IDH1 wild type. All patients were divided into training and validation groups according to the 7∶3 ratio of the random forest model. Seventy-three cases were in training group, and 35 cases were in validation group. Independent predictors of IDH1 mutation were screened by univariate analysis combined with multivariate logistic regression analysis (P<0.05) in order to construct a random forest diagnosis model of general clinical information and conventional MRI morphological features.General clinical information and conventional MRI morphological features included gender, age, umbers of cases of left and right hemispheres, location of tumors, maximum diameter of tumors, peritumoral edema, intratumoral cystic degeneration, enhancement and ADC value of tumors. The ROI was manually outlined by MaZda software in the most obvious level of 5 sequences of tumor mass and the radiomics features were extracted, including the gray-level co-occurrence matrix(GLCM), the run-length matrix(RUN), the absolute gradient(GRA),the auto-regressive model(ARM) and wavelets transform(WAV). The least absolute shrinkage and selection operator (LASSO)regression were used to select image radiomics features with a method of 10 fold cross -validation and to reduce the dimensions. The screened image radiomics labels were combined with the conventional morphological feature independent predictors to construct a multimodal MRI-based random forest model, and the validation data set was used to evaluate the accuracy and diagnostic efficiency of each model. The sensitivity and specificity of conventional MRI morphological feature model and multimodal MRI-based radiomics prediction model were evaluated dynamically by drawing ROC curves, and the prediction efficiency of the two models was quantified by using AUC statistical indicators. The model classification error rate under different outcomes and the classification error rate of out of bag(OOB)were used to evaluate the stability of the multimodal MRI-based random forest model. The contribution rate of each variable to the model was reflected by the characteristic variables importance assessment map.
Results:Univariate regression analysis of the conventional MRI morphological characteristics showed that peritumoral edema, cystic degeneration and enhancement were the three independent predictors of IDH1 gene expression (P<0.01). LASSO algorithm and 10-fold cross-validation identified six robust radiomic features including high frequency coefficients of wavelet transform (WavEnHH_s-4) of T2WI, S(4,4) inverse difference of gray uniformity measurement (InvDfMom),S(5,0) Entropy (entropy),WavEnHH_s-4 of T1WI enhancement, S(1,1) InvDfMom,S(1, -1) Entropy Difference (DifEntrp)of Flair.The error rate of classification for different outcomes and classification error rate of random forest OOB data of multimodal MRI radiomics diagnosis model finally stabilized at 10%. The results of Characteristic Variable Importance Assessment Map: Mean Decrease Accuracy and Mean Decrease Gini index were consistent, which showed that besides three conventional MRI morphological predictors peritumoral edema, enhancement and cystic degeneration, the radiomics labels also played a key role in the model. The results of ROC curve showed that the accuracy, specificity, sensitivity and AUC of conventional MRI morphological feature model were 82.7%, 68.4%, 90.9% and 0.835, respectively, and those of multimodal MRI-based radiomics model were 88.5%, 89.5%, 87.8% and 0.956 respectively.
Conclusion:Multimodal MRI-based radiomics random forest model can improve the predictive efficiency of preoperative glioma IDH1 gene expression type more quantitatively.
