Genetic Polymorphism of a Platelet Glycoprotein IIIa as anInherited Risk Factor for Coronary Artery Disease in Koreans.
10.4070/kcj.1997.27.11.1082
- Author:
Geon Young KIM
;
Dong Soo KIM
;
Hyuck Moon KWON
;
Hyun Seung KIM
- Publication Type:Original Article
- Keywords:
Platelet GlycoproteinIIb/IIIa receptor;
GPIIIa genetic polymorphism;
Risk factor for coronary artery disease
- MeSH:
Acute Coronary Syndrome;
Angina, Unstable;
Blood Platelets*;
Coronary Artery Disease*;
Coronary Vessels*;
Digestion;
DNA;
Genotype;
Humans;
Integrin beta3*;
Myocardial Infarction;
Platelet Aggregation;
Polymerase Chain Reaction;
Polymorphism, Genetic*;
Prevalence;
Risk Factors*;
Thrombosis
- From:Korean Circulation Journal
1997;27(11):1082-1086
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Platelet aggregation and thrombus formation within the coronary artery are major factors in acute coronary syndrome. The platelet glycoproteinIIb/IIIa receptor is a pivotal mediator of platelet aggregation. Recently there have been reports that the genetic polymorphism of GPIIIa is an inherited risk factor for coronary artery thrombosis. This study investigated the relation between the Pl(A) polymorphism and coronary artery disease in Korean patients. METHODS: One hundred patients with acute myocardial infarction and unstable angina were enrolled. Coronary angiogram was performed in eighty-one cases. Genomic DNA from peripheral blood was amplified by polymerase chain reaction. Allele-specific restriction digestion was used to determine the Pl(A) genotype. RESULTS AND CONCLUSIONS: The prevalence of Pl(A2) genotype was zero percent in our study group. All patients had the Pl(A1/A1) genotype. These results suggest that Pl(A) genetic polymorphism of GPIIIa is not an inherited risk factor for coronary artery diseases in Koreans.
