The value of serum presepsin in differentiating Gram-negative bacteria from Gram-positive bacteria and fungal infection in sepsis patients
10.3760/cma.j.issn.1671-0282.2019.10.023
- VernacularTitle: Presepsin区分脓毒症患者G-菌与G+菌、真菌感染的价值
- Author:
Zhihui YE
1
;
Hongguang DING
2
;
Jingkun YE
2
;
Gengxin CAI
2
;
Hongke ZENG
2
;
Miaoyun WEN
2
Author Information
1. Emergency Department, Longgang District Central Hospital of Shen Zhen, Shen Zhen 518116, China
2. Department of Emergency and Critical Care Medicine, Guangdong Provincial People’s Hospital and Guangdong Academy of Medical Sciences, Guangzhou 510080, China
- Publication Type:Clinical Trail
- Keywords:
Sepsis;
Presepsin;
Procalcitonin;
Infection
- From:
Chinese Journal of Emergency Medicine
2019;28(10):1301-1304
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine whether presepsin level can serve as a distinguishing marker between G- bacteria and G+ bacteria, fungal infection in sepsis patients.
Methods:A prospective observation study was conducted on the consecutive patients with positive bacterial cultures in intensive care unit (ICU) from June 2017 to November 2018. The patients were divided into the G- group, G+ group and fungal group. Blood samples were collected upon admission to measure the levels of presepsin and procalcitonin (PCT).
Results:(1) Of the 156 patients met the inclusion criteria. 96 (62% G- rods, 25 (16%) G+ microbes, and 35 (22%) fungi were detected. (2) Presepsin concentrations were significantly higher in the G- group compared with the G+ and fungal groups (P = 0.000). (3) Presepsin level has a higher accuracy in differentiating G- sepsis from Gram+ and fungal sepsis than PCT level [area under the curve (AUC): 0.809 vs 0.712]. The AUC value of a combination of presepsin and PCT level was significantly larger than that of presepsin level alone in differentiating G- sepsis from Gram+ and fungal sepsis (AUC: 0.866 vs 0.809).
Conclusions:In contrast to PCT, presepsin is a good discriminative biomarker in different infections.
