Feasibility and efficacy of percutaneous pulmonary vein stenting for the treatment of patients with severe pulmonary vein stenosis due to fibrosing mediastinitis
10.3760/cma.j.issn.0253-3758.2019.10.008
- VernacularTitle: 经皮肺静脉支架成形术治疗慢性纤维性纵隔炎所致严重肺静脉狭窄初探
- Author:
Xing ZHOU
1
;
Yanjie LI
2
;
Yunshan CAO
3
;
Hongling SU
3
;
Yichao DUAN
3
;
Xin SU
3
;
Rong WEI
3
;
Ai'ai CHU
3
;
Yan ZHU
3
;
Yan HUANG
3
;
Min ZHANG
4
;
Xin PAN
2
Author Information
1. Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China
2. Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China
3. Department of Cardiology, Gansu Provincial Hospital, Lanzhou 730000, China
4. Department of Pathology, Gansu Provincial Hospital, Lanzhou 730000, China
- Publication Type:Clinical Trail
- Keywords:
Mediastinitis;
Stents;
Pulmonary vein stenosis
- From:
Chinese Journal of Cardiology
2019;47(10):814-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the feasibility and safety percutaneous pulmonary vein intervention in patients with severe pulmonary vein stenosis (PVS) caused by fibrosing mediastinitis(FM).
Methods:This retrospective analysis included 5 FM patients (2 male, 3 female, 54-77 years old) confirmed by clinical presentation and chest computed tomography (CT) scan from January to June 2018 who were from Gansu Provincial Hospital and Shanghai Chest Hospital. CT pulmonary angiography (CTPA) further revealed severe PVS caused by fibrotic tissue compression in mediastinum. After selective pulmonary vein angiography, gradually balloon angioplasty was used to expand the pulmonary vein and then stents were implanted in the pre-dilated stenotic pulmonary veins. Evaluation of therapeutic effect was made at 6 months after the procedure.
Results:All of 11 serious compression PVS were treated with stent implantation (diameter: 7-10 mm, length: 17-27 mm). After stenting, degree of pulmonary vein stenosis decreased from (83±16)% to (12±4)% (P<0.01). The minimal diameter of the stenotic pulmonary vein was significantly increased from (0.8±0.5)mm to (7.5±0.8)mm (P<0.01). Trans-stenotic gradient decreased from (27.0±15.1)mmHg (1 mmHg=0.133 kPa) to (2.50±0.58)mmHg (P<0.05). Mean pulmonary pressure measured by cardiac catheter decreased from (45.0±9.0)mmHg to (38.7±8.4)mmHg (P<0.05). One patient experienced cardiac arrest due to vagal nerve reflex during big sizing balloon stent dilation and recovered after cardiopulmonary resuscitation. There were no other serious procedure related complications. During the follow-up, severe stenosis at end of proximal stent was evidenced in 1 patient due to fibrotic compression, and another patient developed in-stent thrombosis due to discontinuation of prescribed anticoagulant.
Conclusion:Percutaneous intervention for severe pulmonary vein stenosis caused by FM is feasible and safe, and can improve hemodynamic caused by the compression of mediastinal vascular structures in these carefully selected patients.
