Research progress in Gasdermin family proteins and their association with diseases
10.3760/cma.j.issn.0254-5101.2019.10.010
- VernacularTitle: Gasdermin家族蛋白及其疾病相关性的研究进展
- Author:
Ran TAO
1
;
Wei LI
1
;
Shiqiang SHANG
1
Author Information
1. Laboratory Center, Children′s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China
- Publication Type:Review
- Keywords:
Gasdermin family;
Pyroptosis;
Inflammatory caspase;
Gasdermin D (GSDMD)
- From:
Chinese Journal of Microbiology and Immunology
2019;39(10):784-787
- CountryChina
- Language:Chinese
-
Abstract:
Gasdermin family (GSDMs), consisting of six proteins (GSDMA, GSDMB, GSDMC, GSDMD, GSDME and DFNB59) in humans and ten proteins (GSDMA1-3, GSDMC1-4, GSDMD, GSDME and DFNB59) in mice, might be involved in multiple physiological and pathological processes, including epithelial cell development, apoptosis, inflammation, carcinogenesis and immune-related diseases. Recent studies confirmed GSDMD, which containing an N-terminal domain with pore-forming activity and a C-terminal domain with structural autoinhibition, as a crucial substrate of inflammatory caspases in pyroptosis, pioneering a new area for structural and functional research on Gasdermin family proteins. This review will summarize the latest progress in the structures, functions and association with diseases of several Gasdermin family proteins.
