Prenatal diagnosis and pregnancy outcomes of sixty-three fetuses with tetralogy of Fallot
10.3760/cma.j.issn.0529-567x.2019.10.003
- VernacularTitle: 63例法洛四联症胎儿的产前诊断及妊娠结局分析
- Author:
Mingbao REN
1
;
Shiping ZHOU
1
;
Lei HOU
1
;
Weiyuan ZHANG
1
;
Xin WANG
1
;
Xiangming FAN
2
;
Xiaorui CHAI
3
Author Information
1. Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China
2. Department of Pediatric Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing 100102, China
3. Experimental Diagnosis Center, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100037, China
- Publication Type:Clinical Trail
- Keywords:
Tetralogy of fallot;
Prenatal diagnosis;
Pregnancy outcome
- From:
Chinese Journal of Obstetrics and Gynecology
2019;54(10):660-665
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the pregnancy outcomes of fetal tetralogy of Fallot and to explore its prenatal diagnosis and treatment procedures.
Methods:The clinical data of 63 cases of fetal tetralogy of Fallot (62 cases were singleton and 1 case was one of twin) were collected retrospectively from November, 2013 to November, 2017 in Beijing Obstetrics and Gynecology Hospital.
Results:(1) Totally, 63 cases out of 46 352 pregnancies were diagnosed fetal tetralogy of Fallot by fetal ultrasonic cardiogram with about 0.136%(63/46 352) occurrence rate, and the mean gestational age was (23±3) weeks. And 50 cases (79%, 50/63) terminated pregnancy by induced labour. (2) Totally, 57 cases (90%,57/63) accepted genetic diagnosis.Eight cases (13%, 8/63) existed chromosome abnormality including 21-trimosy in 6 cases, 18-trisomy in 1 case and 22q11.2 microdeletion syndrome in 1 case; and these 8 cases were determined before 28 gestational weeks. (3) And 13 cases (21%, 13/63) of no fetal genetic abnormality selected to continue pregnancy. Twelve cases underwent full term delivery (5 cases were cesarean section delivery and 7 cases were vaginal delivery). Twelve newborns underwent surgical radical operation on heart malformation and got recovery. One case underwent preterm cesarean section at 35 gestational weeks for one of twin, and the newborn with tetralogy of Fallot was dead. The other the newborns survived and were followed up for tetralogy of Fallot surgery from 1 month to 3 years old after birth and recovered.
Conclusions:Fetal tetralogy of Fallot mainly is diagnosed by ultrasonic cardiogram in the second trimester. The gestational age of diagnosis may be as early as 15 gestational weeks. Fetal tetralogy of Fallot with no genetic abnormality could underwent radical heart malformation operation after birth. It is necessary to undergo genetic testing on fetal tetralogy of Fallot and prenatal multidisciplinary counseling as well.
