High level of hemoglobin during the first trimester of pregnancy associated with the risk of gestational diabetes mellitus
10.3760/cma.j.issn.0529-567x.2019.10.002
- VernacularTitle: 妊娠早期血红蛋白水平与发生妊娠期糖尿病的相关性分析
- Author:
Cuijun GAO
1
;
Xinmei HUANG
2
;
Zaoping CHEN
2
;
Li SHENG
2
;
Jiong XU
2
;
Yue LI
2
;
Xiaoya LI
2
;
Rui ZHANG
2
;
Zhiyan YU
2
;
Bingbing ZHA
2
;
Yueyue WU
2
;
Min YANG
2
;
Heyuan DING
2
;
Tiange SUN
2
;
Yanquan ZHANG
1
;
Ling MA
1
;
Jun LIU
2
Author Information
1. Department of Obstetrics and Gynecology, Hospital of Intergrated Chinese and Western Medicine in Minhang District, Shanghai 200241, China
2. Department of Endocrinology, the Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, China
- Publication Type:Clinical Trail
- Keywords:
Diabetes, gestational;
Hemoglobins;
Pregnancy trimester, first;
Body mass index
- From:
Chinese Journal of Obstetrics and Gynecology
2019;54(10):654-659
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between hemoglobin (Hb) level during the first trimester of pregnancy and gestational diabetes mellitus (GDM).
Methods:A total of 1 276 participants, who underwent scheduled prenatal examination and normal singleton delivery at the Fifth People's Hospital of Shanghai and Hospital of Intergrated Chinese and Western Medicine in Minhang District, from January 2016 to May 2018 were included. There were 99 cases of GDM (GDM group) and 1 177 cases of normal (control group) pregnant women.Based on the serum Hb level during the first trimester of pregnancy, participants were divided into three groups, 236 cases of low Hb level group (Hb<110 g/L), 868 cases of normal Hb level group (110 g/L≤Hb<130 g/L), and 172 cases of high Hb level group (Hb≥130 g/L). Maternal clinical data were collected, including Hb level during the first trimester of pregnancy, three-point blood glucose (BG) of oral glucose tolerance test (OGTT) and fasting insulin during the second trimester of pregnancy. Homeostasis model assessment of insulin resistance index (HOMA-IR) and homeostasis model assessment of pancreatic β cell function index (HOMA-β) were used to evaluate insulin resistance and pancreatic β cell function.
Results:(1) Hb level during the first trimester of pregnancy in GDM group was significantly higher than that in control group [(123±10),(119±11) g/L, P<0.05]. There were no significant difference in gravidity, parity, index of liver and renal function (all P>0.05). (2) Pre-pregnancy body mass index (BMI), 1-hour BG and 2-hour BG of OGTT were significantly increased in the high Hb level group during the first trimester of pregnancy, which were (23±4) kg/m2, (7.3±2.0) mmol/L, and (6.5±1.4) mmol/L (P<0.05), respectively. The pre-pregnancy BMI, 1-hour BG and 2-hour BG of the normal or low Hb level group were (22±3) kg/m2, (6.7±1.6) mmol/L, (6.1±1.2) mmol/L; (22±3) kg/m2, (6.5±1.5) mmol/L, (5.9±1.1) mmol/L, respectively. There were no statistically significant difference in levels of fasting blood glucose, fasting insulin, HOMA-IR and HOMA-β within 3 groups (all P>0.05). (3) In the high Hb level group, prevalence of pregnancy overweight or obesity and GDM were the highest, which were 37.2%(64/172) and 15.1%(26/172), respectively; the differences were statistically significant (all P<0.05). (4) The serum Hb level in the first trimester was positively related with pre-pregnancy BMI (r=0.130, P<0.05), 1-hour BG (r=0.129, P<0.05), 2-hour BG (r=0.134, P<0.05), fasting insulin (r=0.096, P<0.05), and HOMA-IR (r=0.101, P<0.05).Logistic regression indicated that Hb≥130 g/L during the first trimester of pregnancy was an independent risk factor for GDM (OR=2.799, 95%CI: 1.186-6.604; P<0.05).
Conclusion:The high level of Hb (Hb≥130 g/L) during the first trimester of pregnancy is associated with GDM.
