Relative factors of transmural intestinal necrosis in acute superior mesenteric vein thrombosis
10.3760/cma.j.issn.0529-5815.2019.10.009
- VernacularTitle: 急性肠系膜上静脉血栓形成继发透壁性肠坏死的相关因素分析
- Author:
Xinyu WANG
1
;
Weiwei DING
;
Baochen LIU
;
Shilong SUN
;
Xinxin FAN
;
Xingjiang WU
;
Jieshou LI
Author Information
1. Department of General Surgery, Jinling Hospital, Medical School of Nanjing University, Research Institute of General Surgery of People′s Liberation Army, Nanjing 210002, China
- Publication Type:Journal Article
- Keywords:
Venous thrombosis;
Mesenteric veins;
Necrosis
- From:
Chinese Journal of Surgery
2019;57(10):763-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To examine the relative factors of transmural intestinal necrosis(TIN) during multidisciplinary stepwise management facilitating the decision making in patients with acute superior mesenteric vein thrombosis (ASMVT).
Methods:Clinical data of patients with ASMVT admitted to Department of General Surgery, Jinling Hospital from January 2009 to June 2017 were reviewed retrospectively. There were 52 males and 37 females, aging (45.9±12.6) years (range: 20 to 69 years). According to the postoperative pathological results and follow-up, the patients were divided into TIN group (n=31) and non-TIN group(n=58, including 18 cases of intestinal stricture). The related factors were compared between ASMVT patients with TIN and patients without TIN by univariate analysis using t test, U test and χ2 test accordingly, and factors with statistically significance were subsequently submitted to binary Logistic regression analysis. The predictive value and cut-off point of factors were evaluated by receiver operator characteristic(ROC) curve and area under the curve.
Results:In univariate analysis, smoking, hypertension, peritonitis, white blood cell count,haemoglobin, international normalized ratio, blood albumin, thrombosis of superior mesenteric branches vein, free intraperitoneal fluid, decrease of bowel wall enhancement and pneumatosis intestinalis were TIN risk factors (all P<0.05). According to the binary Logistic regression analysis, white blood cell count (OR=1.093, 95%CI: 1.010 to 1.182, P=0.027), thrombosis of the superior mesenteric branches vein (OR=11.519, 95%CI: 1.906 to 69.615, P=0.008), pneumatosis intestinalis (OR=11.140, 95%CI: 2.360 to 52.585, P=0.002) were independent relative factors of TIN in patients with AMI, and the area under the ROC curve of the above factors and predictive model was 0.759 (95%CI: 0.647 to 0.871), 0.745 (95%CI: 0.641 to 0.848), 0.737 (95%CI: 0.621 to 0.854), 0.909 (95%CI: 0.847 to 0.971), respectively. The cutoff value of white blood cell count was 18.1×109/L.
Conclusion:White blood cell levels, superior mesenteric vein branch thrombosis and pneumatosis intestinalis are independent predictors of TIN in ASMVT.
