Prognostic factors of multi-drug resistant organism infection in infected pancreatic necrosis patients
10.3760/cma.j.issn.0529-5815.2019.10.006
- VernacularTitle: 感染性胰腺坏死多重耐药菌感染预后因素分析
- Author:
Xina LI
1
;
Le LI
2
,
3
;
Rui KONG
2
,
3
;
Yingying HU
1
;
Hongtao TAN
2
,
3
;
Hua CHEN
2
,
3
;
Gang WANG
2
,
3
;
Xin HAI
1
;
Bei SUN
2
,
3
Author Information
1. Department of Pharmacy, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
2. Department of Pancreatic and Biliary Surgery, the First Affiliated Hospital of Harbin Medical University
3. Key Laboratory of Hepatosplenic Surgery, Ministry of Education, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
- Publication Type:Journal Article
- Keywords:
Pancreatitis, acute necrotizing;
Infection;
Multi-drug resistant organism;
Infected pancreatic necrosis;
Acinetobacter baumannii
- From:
Chinese Journal of Surgery
2019;57(10):744-749
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prognostic factors of multi-drug resistant organism (MDRO) infection in patients with infected pancreatic necrosis(IPN).
Methods:A retrospective study was performed to assess the MDRO in IPN patients. The clinical data of 104 IPN patients admitted to the Department of Pancreatic and Biliary Surgery, the First Affiliated Hospital of Harbin Medical University from June 2013 to January 2019 were analyzed. Fifty-six patients were allocated in the MDRO group and 48 patients in the non-MDRO group depended on drug sensitivity test. There were 37 males and 19 females in the MDRO group with age of 40 (23) years. The duration time was 3(5) days between onset and admission. In the non-MDRO group, 34 males and 14 females were included with age of (42±14) years. The duration time was 3(4) days between onset and admission. Normally distributed quantitative variables was represented by ±s, non-normally distributed quantitative variables was represented by M(QR). Wilcoxon rank-sum test and χ2 test were used to analyze the data. Univariate and multivariable Logistic regression analytic model were used to figure out the risk factors associated with MDRO infection.
Results:The mean duration of hospital stay was 29.5(31.8) days and hospitalization expenses were CNY 166 991(270 692), which were much higher than those in non-MDRO group (16.5(15.7) days, CNY 56 789(62 354)) (W=1 889, 2 019, both P<0.01). Gram-negative isolates(67.2%, 80/119) were commonly detected in IPN patients.Acinetobacter baumannii was the most common MDRO(27.0%,20/74). Initial use of carbapenem(OR=2.22, 95%CI: 1.02-4.96, P=0.047) and open necrosectomy(OR=10.00, 95%CI: 3.14-44.77, P<0.01) were the potential risk factors for MDRO-induced infections in IPN. Furthermore, the Logistic regression analysis revealed that open necrosectomy was the independent variable for MDRO infections(OR=9.42, 95%CI: 2.92-42.42, P<0.01).
Conclusion:Open necrosectomy is the independent risk factor for the infection of MDRO.
