Endocrine gland-derived vascular endothelial growth factor and placenta-mediated pregnancy complication
10.3760/cma.j.issn.1007-9408.2019.10.009
- VernacularTitle: 内分泌性血管内皮生长因子与胎盘源性妊娠并发症
- Author:
Chanjuan ZENG
1
;
Weishe ZHANG
;
Chenlin PEI
Author Information
1. Department of Obstetrics and Gynecology, Xiangya Hospital of Central South University, Hunan Engineering Research Center of Early Life Development and Disease Prevention, Changsha 410008, China
- Publication Type:Journal Article
- Keywords:
Pregnancy complications;
Placenta diseases;
Vascular endothelial growth factor, endocrine-gland-derived
- From:
Chinese Journal of Perinatal Medicine
2019;22(10):735-739
- CountryChina
- Language:Chinese
-
Abstract:
Placenta-mediated pregnancy complication (PMPC), including preeclampsia, fetal growth restriction and recurrent pregnancy loss, is caused by inadequate trophoblast invasion and abnormal remodeling of maternal spiral arteries in early pregnancy, resulting in adverse perinatal outcomes and affecting the long-term maternal and child health. However, the molecular mechanisms of PMPC remain unclear. Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is highly expressed in human placenta and plays an important role in the development of a normal placenta through promoting placental angiogenesis and inhibiting trophoblast migration and invasion. EG-VEGF dysregulation is closely related to the pathogenesis of PMPC. This review described recent advances in EG-VEGF for better understanding of the underlying mechanism of PMPC and providing a potential biomarker for early diagnosis of PMPC.
