Value of heparin-binding protein in diagnosis of sepsis in adult patients: a Meta-analysis
10.3760/cma.j.issn.2095-4352.2019.10.009
- VernacularTitle: 肝素结合蛋白对成人脓毒症诊断价值的Meta分析
- Author:
Min CHEN
1
;
Jiahui YUAN
2
;
Zhouxin YANG
3
;
Guolong CAI
2
Author Information
1. Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou 310053, Zhejiang, China
2. Department of Critical Care Medicine, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China
3. Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, Hangzhou 310013, Zhejiang, China
- Publication Type:Journal Article
- Keywords:
Sepsis;
Heparin-binding protein;
Diagnosis;
Meta-analysis
- From:
Chinese Critical Care Medicine
2019;31(10):1224-1230
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the application of heparin-binding protein (HBP) in diagnosis of sepsis in adult patients.
Methods:An extensive search for the Chinese and English literatures from the PubMed, Embase, the Cochrane Library, Wanfang data, CNKI and VIP up to July 2019 was performed. The articles regarding HBP for the diagnosing of sepsis in adult patients were enrolled. Two researchers independently extracted related literature. The quality of the studies was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. Meta-Disc 1.4 and STATA 12.0 were used for Meta-analysis. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) were calculated. Summary receiver operating characteristic (SROC) curves and area under the curve (AUC) were used to evaluate the diagnostic performance of HBP for sepsis. Deek funnel plot was used to detect publication bias.
Results:A total of 10 studies with 1 884 patients were included in this Meta-analysis. The quality of the literature was relatively moderate. HBP in plasma were detected by enzyme linked immunosorbent assay (ELISA) in all studies. The studies showed substantial heterogeneity, and random effect model was used for Meta-analysis. The pooled sensitivity, specificity, PLR, NLR, and DOR were 0.80 [95% confidence interval (95%CI) was 0.77-0.83], 0.80 (95%CI was 0.78-0.82), 3.96 (95%CI was 2.45-6.41), 0.28 (95%CI was 0.20-0.39) and 14.63 (95%CI was 6.83-31.30) respectively. The pooled AUC was 0.86 and the Cochran-Q was 0.79. To explore the potential sources of heterogeneity, subgroup analyses were performed based on the severity of the disease, diagnostic criteria and region. However, the results indicated that no methodological covariates affected the diagnostic accuracy of HBP, indicating that there was still unexplained heterogeneity. In addition, the sensitivity analysis by removing individual studies were performed. No outlier study was identified and the results were relatively stable and reliable. Deek funnel plot showed little publication bias.
Conclusions:There is preferable value of HBP for diagnosis of sepsis in adult patients. However, it needs to be further confirmed by large multicenter studies.
