A protective effect conferred by KIR3DL1 and its cognate ligand against cervical cancer among ethnic Han Chinese population and its potential mechanism
10.3760/cma.j.issn.1003-9406.2019.10.022
- VernacularTitle: 中国汉族人群中KIR3DL1及其配体对宫颈癌的保护性作用及机制探讨
- Author:
Jianxin ZHEN
1
;
Leilei ZHU
2
;
Weihong LI
2
;
Haiyan HU
2
;
Zhihui DENG
3
;
Likuan XIONG
1
Author Information
1. Central Laboratory, Shenzhen Baoan Maternal and Child Health Hospital, Shenzhen, Guangdong 518133, China
2. Department of Gynecology, Shenzhen Maternity and Child Healthcare Hospital, Shenzhen, Guangdong 518017, China
3. Institute of Blood Transfusion, Shenzhen Blood Center, Shenzhen, Guangdong 518035, China
- Publication Type:Clinical Trail
- Keywords:
Cervical cancer;
Inhibitory KIR;
KIR3DL1;
Sequence based typing;
Transcription level
- From:
Chinese Journal of Medical Genetics
2019;36(10):1035-1038
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the role of inhibitory KIR (iKIR) and its cognate HLA ligand in the occurrence and development of cervical cancer among ethnic Han Chinese and its potential mechanism.
Methods:Peripheral blood samples from 265 Han Chinese patients with cervical intraepithelial neoplasia (CIN)/cervical cancer and 200 ethnically matched healthy controls were collected. The results of KIR PCR-SSP, HLA PCR-rSSO and KIR3DL1 PCR-SBT, together with cervical cancer data from the TCGA database, were used to assess the association of iKIR genes, receptor-ligand gene combinations, iKIR transcription level in the tumor tissue and the KIR3DL1 alleles with the occurrence and development of cervical cancer.
Results:Among the four iKIR genes (KIR2DL1, 2DL2/3, 3DL1 and 3DL2), the frequencies of KIR3DL1 and KIR3DL1-HLA-Bw4 genes among controls were significantly higher than those of the cervical cancer group (96.5% vs. 87.0%, P = 0.018; 81.5% vs. 64.8%, P=0.009). The survival rate of cervical cancer patients with a high transcription level of KIR3DL1 in tumor tissues was significantly higher than those with a low/medium transcription level (P = 0.028). The frequency of strong-inhibitory and high-expression KIR3DL1*01502 allele among the healthy population was significantly higher than that of the cervical cancer group (76.0% vs. 59.3%, P = 0.015).
Conclusion:Combined KIR3DL1 and KIR3DL1-HLA-Bw4 can confer a protective effect against the development of cervical cancer, which may be attributed to the strong-inhibitory and high-expression allele of KIR3DL1*01502.
