Epidemiological Aspects of Pertussis among Adults and Adolescents in a Korean Outpatient Setting: A Multicenter, PCR-Based Study.
10.3346/jkms.2014.29.9.1232
- Author:
Sunghoon PARK
1
;
Sun Hwa LEE
;
Ki Hyun SEO
;
Kyeong Cheol SHIN
;
Yong Bum PARK
;
Myung Goo LEE
;
Kwang Ha YOO
;
Hui Jung KIM
;
Jae Seuk PARK
;
Jae Hwa CHO
;
Yongchun KO
;
Soo Keol LEE
;
Ki Tae CHEON
;
Do Il KIM
;
Jun Wook HA
;
Jae Myung LEE
;
Ji Won SUHR
;
Eui Hun JEONG
;
Ki Suck JUNG
Author Information
1. Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea. pulmoks@hallym.ac.kr
- Publication Type:Original Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
- Keywords:
Pertussis;
Adult;
Hospitals;
Incidence;
Seasons
- MeSH:
Adolescent;
Adult;
Bordetella pertussis/*genetics;
Child;
DNA, Bacterial/*analysis;
Demography;
Female;
Humans;
Incidence;
Male;
Middle Aged;
Multivariate Analysis;
Odds Ratio;
*Polymerase Chain Reaction;
Republic of Korea/epidemiology;
Seasons;
Vomiting/etiology;
Whooping Cough/*epidemiology/microbiology/pathology;
Young Adult
- From:Journal of Korean Medical Science
2014;29(9):1232-1239
- CountryRepublic of Korea
- Language:English
-
Abstract:
Epidemiological data of Bordetella pertussis infection among adolescents and adults are limited in Korea. Patients (> or = 11 yr of age) with a bothersome cough for less than 30 days were enrolled during a 1-yr period at 22 hospitals in Korea. Nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and for bacteriologic culture. In total, 490 patients were finally enrolled, and 34 (6.9%) patients tested positive for B. pertussis; cough duration (14.0 days [7.0-21.0 days]) and age distribution were diverse. The incidence was the highest in secondary referral hospitals, compared to primary care clinics or tertiary referral hospitals (24/226 [10.6%] vs. 3/88 [3.4%] vs. 7/176 [4.0%], P = 0.012), and the peak incidence was observed in February and August (15.8% and 15.9%), with no confirmed cases between March and June. In the multivariate analysis, post-tussive vomiting was significantly associated with pertussis (odds ratio, 2.508; 95% confidence interval, 1.146-5.486) and secondary referral hospital showed a borderline significance. In conclusion, using a PCR-based method, 6.9% of adolescent and adult patients with an acute cough illness had pertussis infection in an outpatient setting. However, hospital levels and seasonal trends must be taken into account to develop a better strategy for controlling pertussis.
