Anti-Mullerian Hormone Levels in the Follicular Fluid of the Preovulatory Follicle: A Predictor for Oocyte Fertilization and Quality of Embryo.
10.3346/jkms.2014.29.9.1266
- Author:
Jee Hyun KIM
1
;
Jung Ryeol LEE
;
Hye Jin CHANG
;
Byung Chul JEE
;
Chang Suk SUH
;
Seok Hyun KIM
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. suhcs@snu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Anti-Mullerian Hormone;
Follicular Fluid;
Oocyte Competence;
Embryo Quality;
In Vitro Fertilization
- MeSH:
Adult;
Anti-Mullerian Hormone/*analysis;
Embryo, Mammalian/*cytology;
Female;
Fertilization in Vitro;
Follicular Fluid/*metabolism;
Humans;
Oocytes/cytology;
Prospective Studies
- From:Journal of Korean Medical Science
2014;29(9):1266-1270
- CountryRepublic of Korea
- Language:English
-
Abstract:
This prospective study investigated the relationship between anti-Mullerian hormone (AMH) level in the follicular fluid (FF) and the quality of the oocyte and embryo. A total of 65 FF samples from 54 women were included in this study. FF was collected from the largest preovulatory follicle sized> or =20 mm of mean diameter from each ovary. Samples were divided into 3 groups according to the FF AMH levels: below the 33th percentile (low group, FF AMH<2.1 ng/mL, n=21), between the 33th and the 67th percentile (intermediate group, FF AMH=2.1-3.6 ng/mL, n=22), and above the 67th percentile (high group, FF AMH>3.6 ng/mL, n=22). The quality of the ensuing oocytes and embryos was evaluated by fertilization rate and embryo score. FF AMH levels correlated positively with the matched embryo score on day 3 after fertilization (r=0.331, P=0.015). The normal fertilization rate was significantly lower in the low group than in the intermediate group (61.9% vs. 95.5% vs. 77.3%, respectively, P=0.028). Our results suggest that the FF AMH level could be a predictor of the ensuing oocyte and embryo quality.
