Analysis of 18 cases of toxic encephalopathy caused by occupational acute 1, 2-dichloroethane poisoning
10.3760/cma.j.issn.1001-9391.2019.10.013
- VernacularTitle: 职业性急性1，2-二氯乙烷中毒致中毒性脑病18例分析
- Author:
Yuquan CHEN
1
,
2
;
Yuqiang LIN
1
,
2
;
Yili ZHANG
1
;
Wenzhong JIANG
1
;
Zhiqian YANG
1
;
Yimin LIU
1
,
2
Author Information
1. Guangzhou Prevention and Treatment Hospital of Occupational Diseases, Guangzhou 510620, China
2. School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
- Publication Type:Journal Article
- Keywords:
Occupational diseases;
Ethylene dichloroes;
Poisoning
- From:
Chinese Journal of Industrial Hygiene and Occupational Diseases
2019;37(10):778-780
- CountryChina
- Language:Chinese
-
Abstract:
Retrospective analysis of 18 cases of occupational acute 1, 2-dichloroethane (1, 2-DCE) poisoning. The results showed that all patients have the main manifestations such as dizziness, headache, unresponsiveness and other symptoms of nervous system damage; Brain CT showed varying degrees of diffuse white matter lesions. Brain MRI showed extensive involvement of white matter in both cerebral hemispheres. Affected white matter area presented low intensity on T1WI, hyperintensity on T2WI and T2-Flair; Lumbar puncture examination of cerebrospinal fluid (CSF) pressure (262.5±48.39) mm H2O; After treatment, the required time for CSF pressure to restore was (161.56±75.27) days (50-280) days. Summary, Occupational acute 1, 2-DCE poisoning caused by toxic encephalopathy can be manifested as persistent abnormalities in CSF pressure, and the CSF pressure drops slowly during treatment; Early head CT and lumbar puncture examination will be helpful for early detection of intracranial pressure in toxic encephalopathy caused by acute 1, 2-DCE poisoning. Dynamic monitoring of CSF provides guidance for acute 1, 2-DCE poisoning with a long time of treatment and various types of dehydrating agents.
