Fecal microbiota transplantation as a novel therapy for severe psoriasis
10.3760/cma.j.issn.0578-1426.2019.10.011
- VernacularTitle: 肠微生态移植重建治疗重度银屑病的临床研究
- Author:
Guang YIN
1
;
Jianfeng LI
2
;
Yufa SUN
3
;
Xiao DING
1
;
Jiaqi ZENG
2
;
Ting ZHANG
4
;
Lihua PENG
2
;
Yunsheng YANG
2
;
Hua ZHAO
1
Author Information
1. Department of Dermatology, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing 100853, China
2. Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Chinese PLA Medical College, Beijing 100853, China
3. Department of Health Care, Chinese PLA Joint Staff Headquarters Guard Bureau, Beijing 100017, China
4. Training Department, Chinese PLA General Hospital, Beijing 100853, China
- Publication Type:Case Reports
- Keywords:
Fecal microbiota transplantation;
Psoriasis;
Irritable bowel syndrome
- From:
Chinese Journal of Internal Medicine
2019;58(10):782-785
- CountryChina
- Language:Chinese
-
Abstract:
To explore the therapeutic effect of fecal microbiota transplantation (FMT) for severe psoriasis. A patient, male, 36 years old, diagnosed as severe plaque psoriasis for 10 years and irritable bowel syndrome (IBS) for 15 years, was administrated twice FMT via both upper endoscopy and colonoscopy with a 5-week interval. The following items were used to evaluate responses: body surface area (BSA), psoriasis area and severity index (PASI), dermatology life quality index (DLQI), histological examination, intestinal symptoms, adverse reactions and serum level of tumor necrosis factor (TNF)-α. After second FMT treatment for 5 weeks, aforementioned items were improved greatly compared with those before treatment. Moreover, IBS was completely relieved and no adverse reactions were observed during the treatment and follow-up. In conclusion, FMT could be a novel therapy for psoriasis. Further clinical trials are needed to provide solid evidences.
