Red blood cell lifespan detected by endogenous carbon monoxide breath test in patients with polycythemia vera
10.3760/cma.j.issn.0578-1426.2019.10.010
- VernacularTitle: 内源性一氧化碳呼气试验检测真性红细胞增多症红细胞寿命
- Author:
Qingyan GAO
1
;
Yangmin ZHU
;
Jing HU
;
Jie GUO
;
Benlin BAO
;
Xin ZHAO
;
Lei YE
;
Yuan LI
;
Guangxin PENG
;
Jianping LI
;
Yang LI
;
Huihui FAN
;
Lin SONG
;
Liping JING
;
Li ZHANG
;
Fengkui ZHANG
Author Information
1. Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
- Publication Type:Journal Article
- Keywords:
Polycythemia vera;
Red blood cell lifespan;
Carbon monoxide breath test
- From:
Chinese Journal of Internal Medicine
2019;58(10):777-781
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To detect the red blood cell lifespan in patients with polycythemia vera (PV), and explore the influencing factors.
Methods:From February 2017 to December 2018, 27 patients with PV at Blood Diseases Hospital, Chinese Academy of Medical Science and 18 normal controls were recruited. Red blood cell lifespan was detected by endogenous carbon monoxide (CO) breath test. The related factors were analyzed.
Results:The average red blood cell lifespan of 27 PV patients was 80 (range, 35-120) days (d), which was significantly shorter than that of the normal controls [110.5(69-166) d, P<0.05], namely 35.3 d shorter. The red blood cell lifespan of ten newly diagnosed patients and 17 patients who were treated with hydroxyurea and/or interferon were 98 (35-117) d and 69 (45-120) d, respectively, which were both shorter than that of the normal control (P=0.010, 0.000). Correlation analysis showed that red blood cell lifespan of patients with newly diagnosed PV was associated with JAK2 mutation allele burden (r=0.900, P=0.037), peripheral blood lymphocyte count (r=-0.742, P=0.014) and the level of serum vitamin B12 (r=-0.821, P=0.023).
Conclusion:The lifespan of red blood cells in patients with PV is about one-third shorter than normal, and is related to JAK2 mutation allele burden, absolute lymphocyte count, and serum vitamin B12 level.
