Effect of PM2.5 exposure on thyroid function in SD rats
10.3760/cma.j.issn.1000-6699.2019.10.012
- VernacularTitle: PM2.5暴露对SD大鼠甲状腺功能的影响
- Author:
Jianan LANG
1
;
Baoyu ZHANG
1
;
Dong ZHAO
1
;
Longfei GUAN
2
;
Ying FU
1
Author Information
1. Beijing Key Laboratory of Diabetes Research and Care, Center for Endocrine Metabolism and Immune Diseases, Luhe Hospital, Capital Medical University, Beijing 101149, China
2. China-America Institute of Neuroscience, Beijing Luhe Hospital, Capital Medical University, Beijing 101149, China
- Publication Type:Journal Article
- Keywords:
PM2.5;
Thyroid function
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(10):874-877
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of PM2.5 exposure on the thyroid function in male SD rats.
Methods:Adult Sprague-Dawley rats were divided into " filtered air" (FA) and " PM2.5" groups. These rats exposed to the 2 kinds of air for 12 weeks were killed and their plasma and thyroid tissues were taken for investigation. The morphological status and pathological changes of thyroid tissue were observed after H&E staining. The levels of triiodothyronine (T3), free triiodothyronine (FT3), thyroxine(T4), free thyroxine (FT4), anti-thyroglobulin antibody (TGAb), anti-thyroid peroxidase antibody (TPOAb), thyrotropin (TSH), tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) in rats were measured by ELISA.
Results:The results showed that there was no significant difference in body weight between two groups after 12 weeks of exposure to either filtered air or PM2.5. No pathological changes and significant differences were observed in the thyroid tissues of two groups after HE staining. There were no significant differences in plasma levels of T4, T3, FT3, TNF-α, and IL-6 between two groups. However, compared with rats exposed to filtered air, rats exposed to PM2.5 had significantly lower plasma FT4[(3.81±1.23) vs (6.02±2.40)pmol/L, P<0.01] and higher TSH [(5.63±1.74) vs (4.29±1.37) mU/L, P<0.05] levels.
Conclusion:The exposure to PM2.5 for a period of 12 weeks may lead to the decrease of FT4 and increase of TSH in rats.
