Comparison of effectiveness and safety of high-dose native vitamin D versus active vitamin D in the treatment of hypoparathyroidism
10.3760/cma.j.issn.1000-6699.2019.10.009
- VernacularTitle: 大剂量普通维生素D和活性维生素D治疗甲状旁腺功能减退症有效性和安全性的比较
- Author:
Sixing CHEN
1
;
Yabing WANG
1
;
Ou WANG
1
;
Min NIE
1
;
Yan JIANG
1
;
Mei LI
1
;
Weibo XIA
1
;
Xiaoping XING
1
Author Information
1. Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China
- Publication Type:Clinical Trail
- Keywords:
Non-surgical hypoparathyroidism;
Native vitamin D;
Active vitamin D
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(10):859-863
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effectiveness and safety of high-dose native vitamin D versus active vitamin D by retrospective analysis of clinical data in patients with non-surgical hypoparathyroidism (ns-HP) in our hospital.
Methods:ns-HP patients with stable therapeutic schedule in recent three years were included. According to the vitamin D agents used, patients were divided into three groups: active vitamin D group, native vitamin D group, and mixed vitamin D group. The effectiveness was evaluated by analysis of markers including post-treatment serum calcium, incidence of hypocalcemia, hypocalcemic symptoms and signs. The safety was evaluated in various groups by analyzing incidences of hypercalcemia and hypercalciuria, glomerular filtration rate, percentage of thiazide diuretic use, nephrocalcinosis or renal stone.
Results:Patients in active vitamin D group were more likely to experience episodes of hypocalcemia compared with those in native group (32.94%±21.46% vs 24.86%±10.1%, P<0.05). No significant differences in other indexes for assessing effectiveness and safety were found among three groups (P>0.05).
Conclusions:Under the circumstance of regular follow-up, both high-dose native vitamin D and active vitamin D could treat ns-HP effectively and safely. Native vitamin D may be better in maintaining eucalcemia and reducing incidence of hypocalcemia compared with active vitamin D.
