Relationship between serum CTRP6 level and insulin resistance in patients with newly diagnosed type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2019.10.006
- VernacularTitle: 新诊断2型糖尿病患者血清CTRP6与胰岛素抵抗的相关性研究
- Author:
Jiaoyang LI
1
;
Min LIU
1
;
Xiaoyan QI
1
;
Yadi WANG
1
;
Li RAN
1
;
Tao HONG
1
;
Jing YANG
1
;
Gebo WEN
1
;
Jianghua LIU
1
;
Xinhua XIAO
1
Author Information
1. Department of Endocrinology and Metabolism, the First Affiliated Hospital of University of South China, Hengyang 421001, China
- Publication Type:Clinical Trail
- Keywords:
C1q/TNF-related protein-6;
Diabetes mellitus, type 2;
Inflammation
- From:
Chinese Journal of Endocrinology and Metabolism
2019;35(10):843-847
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between serum C1q and tumor necrosis factor related protein 6(CTRP6) level and insulin resistance in patients with newly diagnosed type 2 diabetes mellitus (T2DM).
Methods:A total of 167 patients with newly diagnosed T2DM in the outpatient department of our hospital were recruited from April 2016 to March 2017 and 165 subjects with normal glucose tolerance were used as the control group. The concentrations of CTRP6, interleukin 6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and tumor necrosis factor α (TNF-α) were determined by ELISA.
Results:Circulating CTRP6 level was significantly higher in T2DM group than that in control group [(652.54±132.57) vs (521.28±119.93)μg/L, P<0.01] after adjusting age and body mass index (BMI). Overweight/obese subjects revealed higher CTRP6 levels compared with those in lean individuals. In addition, circulating CTRP6 level was positively correlated with BMI, waist circumference, fasting plasma glucose, postprandial 2h plasma glucose, HbA1C, fasting insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride (TG), IL-6, MCP-1, highly sensitive C-reactive protein (hs-CRP), and TNF-α, while it was inversely correlated with high-density lipoprotein-cholesterol(P<0.01). Multivariate linear regression analysis showed that TG, HOMA-IR, and IL-6 were independent factors for CTRP6 level. After adjusting for potential confounders, CTRP6 remained an independent risk factor for T2DM. Trend test showed that the increase in CTRP6 level was significantly linear with the occurrence of T2DM. The analysis of receiver operating characteristic curves revealed that the area under the curve for circulating CTRP6 to predict T2DM was 0.730.
Conclusions:CTRP6 may be associated with insulin resistance.
