Anti-inflammatory effects of a Houttuynia cordata supercritical extract.
10.4142/jvs.2010.11.3.273
- Author:
Sunhee SHIN
1
;
Seong Soo JOO
;
Jeong Hee JEON
;
Dongsun PARK
;
Min Jung JANG
;
Tae Ook KIM
;
Hyun Kyu KIM
;
Bang Yeon HWANG
;
Ki Yon KIM
;
Yun Bae KIM
Author Information
1. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Korea. solar93@cbu.ac.kr
- Publication Type:Brief Communication ; Research Support, Non-U.S. Gov't ; Comparative Study ; Evaluation Studies
- Keywords:
carrageenan;
dexamethasone;
Houttuynia cordata extract;
indomethacin;
inflammation
- MeSH:
Analysis of Variance;
Animals;
Anti-Inflammatory Agents/*pharmacology;
Carrageenan;
Cell Line, Tumor;
Dexamethasone/pharmacology;
Dinoprostone/metabolism;
Drugs, Chinese Herbal/*pharmacology;
Immunoenzyme Techniques;
Indomethacin/pharmacology;
Male;
Mice;
Mice, Inbred ICR;
Nitric Oxide/metabolism;
Signal Transduction/*drug effects;
Therapeutic Irrigation;
Tumor Necrosis Factor-alpha/metabolism
- From:Journal of Veterinary Science
2010;11(3):273-275
- CountryRepublic of Korea
- Language:English
-
Abstract:
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in a carrageenan-air pouch model. HSE (200 mg/kg, oral) suppressed exudation and albumin leakage, as well as inflammatory cell infiltration. Dexamethasone (2 mg/kg, i.p.) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content. HSE lowered tumor-necrosis factor (TNF)-alpha and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased TNF-alpha and PGE2. The suppressive activity of HSE on NO and PGE2 production was confirmed in RAW 264.7. These results demonstrate that HSE exerts anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase II-PGE2 pathways.
