The Effect of Rush Immunotherapy with House Dust Mite in the Production of IL-5 and IFN-gamma from the Peripheral Blood T Cells of Asthmatic Children.
10.3346/jkms.2009.24.3.392
- Author:
Hyo Bin KIM
1
;
Hyun Seung JIN
;
So Yeon LEE
;
Ja Hyeong KIM
;
Bong Seong KIM
;
Seong Jong PARK
;
Soo Jong HONG
Author Information
1. Department of Pediatrics, Asthma & Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea.
- Publication Type:Original Article ; Controlled Clinical Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Rush Immunotherapy;
T Cell;
Interferon-gamma;
Asthma;
House Dust Mite
- MeSH:
Adolescent;
Animals;
Antigens, Dermatophagoides/immunology;
Asthma/diagnosis/*immunology/*therapy;
Child;
*Desensitization, Immunologic;
Female;
Humans;
Interferon-gamma/*metabolism;
Interleukin-5/*metabolism;
Male;
Pyroglyphidae/*immunology;
Severity of Illness Index;
T-Lymphocytes/*immunology/metabolism
- From:Journal of Korean Medical Science
2009;24(3):392-397
- CountryRepublic of Korea
- Language:English
-
Abstract:
Although the mechanisms are unclear, rush immunotherapy (RIT) may be effective to treat allergic diseases. We investigated the long-term modifications of cellular immunity as a mechanism of RIT. The RIT group, included 15 house dust mite (HDM)-sensitized asthmatic children, received RIT only with Dermatophagoides farinae (Der f) and Dermatophagoides pteronyssinus (Der p), whereas the control group, consisted of 10 HDM-sensitized asthmatic children, did not receive RIT. The asthma symptom scores and the skin reactivities to Der f were measured. The cellular proliferative responses and intracellular interleukin (IL)-5 and interferon (IFN)-gamma productions from peripheral blood T cells were also measured before, 8 weeks and 1 yr after RIT. The symptom scores, skin reactivity to Der f and cellular proliferative responses to Der f were decreased significantly after 8 weeks and maintained until 1 yr of RIT. The IFN-gamma/IL-5 ratio of the CD3(+) and CD4(+) cells were increased significantly after 8 weeks and maintained until 1 yr of RIT, while there were no changes in the control group. These data indicate that the continuous functional modification from Th2 to Th1 phenotype of the CD4(+) T cells are developed after RIT in the asthmatic children sensitized with HDM.
