Comparison of Parecoxib and Proparacetamol in Endoscopic Nasal Surgery Patients.
10.3349/ymj.2008.49.3.383
- Author:
Yigal LEYKIN
1
;
Andrea CASATI
;
Alessandro RAPOTEC
;
Massimiliano DALSASSO
;
Luigi BARZAN
;
Guido FANELLI
;
Tommaso PELLIS
Author Information
1. Department of Anaesthesia and Intensive Care, Santa Maria degli Angeli Hospital, Via Montereale 24, 33170 Pordenone, Italy. yigal.leykin@aopn.fvg.it
- Publication Type:Original Article ; Comparative Study ; Randomized Controlled Trial
- Keywords:
Postoperative pain;
parecoxib;
proparacetamol;
analgesia;
nasal surgery
- MeSH:
Acetaminophen/administration & dosage/analogs & derivatives/*therapeutic use;
Adult;
Analgesics, Non-Narcotic/administration & dosage/therapeutic use;
Cyclooxygenase Inhibitors/administration & dosage/therapeutic use;
Double-Blind Method;
Endoscopy/methods;
Female;
Humans;
Infusions, Intravenous;
Injections, Intravenous;
Isoxazoles/administration & dosage/*therapeutic use;
Male;
Middle Aged;
Nasal Polyps/surgery;
Pain, Postoperative/*drug therapy;
Prodrugs/administration & dosage/*therapeutic use;
Prospective Studies;
Sinusitis/surgery;
Treatment Outcome
- From:Yonsei Medical Journal
2008;49(3):383-388
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The aim of the study was to compare the efficacy of parecoxib for postoperative analgesia after endoscopic turbinate and sinus surgery with the prodrug of acetaminophen, proparacetamol. MATERIALS AND METHODS: Fifty American Society of Anesthesiology (ASA) physical status I-II patients, receiving functional endoscopic sinus surgery (FESS) and endoscopic turbinectomy, were investigated in a prospective, randomized, double-blind manner. After local infiltration with 1% mepivacaine, patients were randomly allocated to receive intravenous (IV) administration of either 40mg of parecoxib (n=25) or 2g of proparacetamol (n=25) 15 min before discontinuation of total IV anaesthesia with propofol and remifentanil. A blinded observer recorded the incidence and severity of pain at admission to the post anaesthesia care unit (PACU) at 10, 20, and 30 min after PACU admission, and every 1 h thereafter for the first 6 postoperative h. RESULTS: The area under the curve of VAS (AUC(VAS)) calculated during the study period was 669 (28-1901) cm·min in the proparacetamol group and 635 (26-1413) cm·min in the parecoxib group (p=0.34). Rescue morphine analgesia was required by 14 patients (56%) in the proparacetamol group and 12 patients (48%) in the parecoxib (p> or=0.05), while mean morphine consumption was 5-3.5mg and 5-2.0mg in the proparacetamol groups and parecoxib, respectively (p> or=0.05). No differences in the incidence of side effects were recorded between the 2 groups. Patient satisfaction was similarly high in both groups, and all patients were uneventfully discharged 24h after surgery. CONCLUSION: In patients undergoing endoscopic nasal surgery, prior infiltration with local anaesthetics, parecoxib administered before discontinuing general anaesthetic, is not superior to proparacetamol in treating early postoperative pain.
