The Relationship between the serum intercellular adhesion molecule-1 level and the prognosis of the disease in lung cancer.
- Author:
Hun Sub SHIN
1
;
Chan Hee JUNG
;
Hyun Duk PARK
;
Seung Sei LEE
Author Information
1. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. lss987@samsung.co.kr
- Publication Type:Original Article
- Keywords:
Lung cancer;
ICAM-1;
Soluble ICAM-1
- MeSH:
Adhesives;
Carcinoma, Hepatocellular;
Carcinoma, Non-Small-Cell Lung;
Colonic Neoplasms;
Enzyme-Linked Immunosorbent Assay;
Extracellular Matrix;
Humans;
Intercellular Adhesion Molecule-1*;
Lung Neoplasms*;
Lung*;
Melanoma;
Pancreatic Neoplasms;
Prognosis*;
Small Cell Lung Carcinoma;
Urinary Bladder Neoplasms
- From:Korean Journal of Medicine
2003;64(4):429-434
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Adhesion molecule is related to cell-cell interaction and inflammatory interaction. In addition, adhesive interactions between tumor cells and adjacent cells and/or extracellular matrix are important role in the complex process of tumor growth and develpment. Of these adhesion molecules, expression of intercellular adhesion molecule-1 (ICAM-1) have been identified in colon cancer, bladder cancer, lung cancer, melanoma, pancreatic cancer, hepatocellular carcinoma. In the current study, we analyzed serum ICAM-1 concentrations to investigate the relationship between the sICAM-1 level and the prognosis of the disease in patients with lung cancer METHODS: Serum sICAM-1 was measured in 84 patients with lung cancer according to the pathologic types and clinical staging using ICAM-1 ELISA kit. The Kaplan-Meier method was used to analyse survival time. RESULTS: There was no difference in sICAM-1 concentration among the stage of lung cancer. And no difference was observed among histologic tumor types with regard to sICAM-1 concentration. The overall survival of patients with low sICAM-1 concentration (<306 ng/mL) were longer than that of patients with high concentration (>or=306 ng/mL) in non-small cell lung cancer patients, but no difference was observed in small cell lung cancer patients. CONCLUSION: These results suggest that high levels of sICAM-1 reflect the poor prognosis of patients with non-small cell lung cancer.
