Correlations among C-reactive protein, hemostatic factors, apolipoproteins, and cardiac troponin T in patients undergoing continuous ambulatory peritoneal dialysis.
- Author:
Yu Mi KIM
1
;
Jang Won SEO
;
Jai Won CHANG
;
Sang Koo LEE
;
Soon Bae KIM
;
Jung Sik PARK
Author Information
1. Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea. sbkim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Arteriosclerosis;
C-reactive protein;
Hemostatic factor;
Lipid;
Troponin T
- MeSH:
Apolipoprotein A-I;
Apolipoproteins B;
Apolipoproteins*;
Arteriosclerosis;
C-Reactive Protein*;
Cholesterol;
Dialysis;
Fibrinogen;
Humans;
Inflammation;
Mortality;
Multivariate Analysis;
Peritoneal Dialysis, Continuous Ambulatory*;
Prealbumin;
Risk Factors;
Thallium;
Tomography, Emission-Computed, Single-Photon;
Triglycerides;
Troponin T*;
Troponin*;
von Willebrand Factor
- From:Korean Journal of Medicine
2003;64(4):442-451
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There are several risk factors in the development of arteriosclerosis, including lipid parameters, inflammatory markers, and hemostatic factors. Efforts should be undertaken to identify the relationship among risk factors and underlying mechanisms of arteriosclerosis to improve long-term survival in dialysis patients. This study was performed to evaluate correlations among these risk factors and cardiac troponin T (cTnT) in patients undergoing continuous ambulatory peritoneal dialysis (CAPD). METHODS: Seventy-seven CAPD pateints (M: 50, F: 27; mean age 52.8+/-12.4 years) were enrolled in this study. We measured blood level of total cholesterol (TC), triglycerides (TG), HDL-cholesterol (HDL-C), apolipoprotein A-1 (apoA-1), apolipoprotein B (apoB), C-reactive protein (CRP), fibrinogen, d-dimer, von Willebrand factor (vWF), and cTnT monthly for three times. Thallium SPECT was performed in 32 of 77 patients. RESULTS: Significant positive correlation was found between CRP and fibrinogen (r=0.71, p<0.001). CRP was also positively correlated with vWF (r=0.29, p=0.01). Significant inverse correlation was observed between prealbumin and CRP (r=-0.33, p=0.004). HDL-C and apoA-1 were also inversely correlated with CRP (r=-0.26, p=0.04; r=-0,27, p=0.02) and apoB was positively correlated with CRP (r=0.24, p=0.02). Multivariate analysis revealed that fibrinogen, prealbumin, HDL-C, and apoA-1 correlated independently with CRP. In patients with diabetes (n=35), cTnT levels were sigificantly higher than those in patients without diabetes (p<0.001), whereas albumin and prealbumin levels were significantly lower in patients with diabetes than those in patients without diabetes (p<0.001, p=0.002). Serum apoB, triglyceride, and total cholesterol were higher among patients with positive results in thallium SPECT than those with negative results. CONCLUSION: It seems that inflammation is associated with an enhanced cardiovascular risk profile such as hemostatic factors and apolipoproteins. cTnT may be a useful predictive marker for mortality in dialysis patients.
