Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report.
- Author:
Yoomi CHOI
1
;
Kyoung Yul LEE
;
Min Hye JANG
;
Hyesil SEOL
;
Sung Won KIM
;
So Yeon PARK
Author Information
1. Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Invasive carcinoma;
Phyllodes tumor;
Breast;
Cribriform
- MeSH:
Adenocarcinoma;
Breast;
Diagnosis, Differential;
Female;
Humans;
Middle Aged;
Neoplasms, Fibroepithelial;
Phyllodes Tumor
- From:Korean Journal of Pathology
2012;46(2):205-209
- CountryRepublic of Korea
- Language:English
-
Abstract:
Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.
