A Case of Voltage Gated Potassium Channel Antibodies-associated Nonparaneoplastic Limbic Encephalitis.
- Author:
Yoseo WON
1
;
Ji Yoon KIM
;
Hyung Jun PARK
;
Soochul PARK
;
Jong Doo LEE
;
Il Sang CHOI
Author Information
1. Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. scpark@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Nonparaneoplastic limbic encephalitis;
Voltage gated potassium channel antibody;
Immunotherapy
- MeSH:
Antibodies;
Humans;
Immunotherapy;
Korea;
Limbic Encephalitis*;
Neurons;
Potassium Channels, Voltage-Gated*;
Prognosis;
Steroids
- From:Journal of the Korean Neurological Association
2006;24(2):148-152
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Limbic encephalitis has been reported usually as an autoimmune complication related to onconeuronal antigen of underlying cancer with poor prognosis. Antibodies reactive with neuronal voltage-gated potassium channels (VGKCs) are recently recognized as a pathogenic cause in nonparaneoplastic limbic encephalitis, which is responsive to immunotherapy. We report a patient who had subacute encephalopathy with clinical and radiographic evidences of limbic encephalitis. The patient was seropositive for VGKC antibodies and resulted in a good prognosis with steroids. This has not yet been reported in Korea.
