Synergy of Arbekacin-based Combinations Against Vancomycin Hetero-intermediate Staphylococcus aureus.
10.3346/jkms.2006.21.2.188
- Author:
Ji Young LEE
1
;
Won Sup OH
;
Kwan Soo KO
;
Sang Taek HEO
;
Chi Sook MOON
;
Hyun Kyun KI
;
Sungmin KIEM
;
Kyong Ran PECK
;
Jae Hoon SONG
Author Information
1. Asian-Pacific Research Foundation for Infectious Diseases (ARFID), Korea. jhsong@ansorp.org
- Publication Type:Original Article ; In Vitro ; Research Support, Non-U.S. Gov't
- Keywords:
Arbekacin;
habekacin;
Rifampin;
Sultamicillin;
Teicoplanin quinipristin-dalfopristin;
Vancomycin Resistance;
Staphylococcus aureus;
hetero-VISA;
Time-kill assay
- MeSH:
Virginiamycin/administration & dosage;
Vancomycin/*administration & dosage;
Teicoplanin/administration & dosage;
Sulbactam/administration & dosage;
Staphylococcus aureus/*drug effects/isolation & purification;
Staphylococcal Infections/drug therapy/microbiology;
Microbial Sensitivity Tests;
Methicillin Resistance;
Humans;
Drug Synergism;
Drug Resistance, Bacterial;
Dibekacin/administration & dosage/*analogs & derivatives;
Anti-Bacterial Agents/*administration & dosage;
Ampicillin/administration & dosage;
Aminoglycosides/*administration & dosage
- From:Journal of Korean Medical Science
2006;21(2):188-192
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study was undertaken to evaluate the in vitro activities of arbekacin-based combination regimens against vancomycin hetero-intermediate Staphylococcus aureus (hetero-VISA). Combinations of arbekacin with vancomycin, rifampin, ampicillin-sulbactam, teicoplanin, or quinipristin-dalfopristin against seven hetero-VISA strains and two methicillin-resistant S. aureus strains were evaluated by the time-kill assay. The combinations of arbekacin with vancomycin, teicoplanin, or ampicillinsulbactam showed the synergistic interaction against hetero-VISA strains. Data suggest that these arbekacin-based combination regimens may be useful candidates for treatment options of hetero-VISA infections.
