Clinical Study of the Intravenous Amiodarone in Acute Myocardial Infarction with Life-Threatening Refractory Ventricular Tachyarrhythmias.
10.4070/kcj.1998.28.8.1314
- Author:
Yu Jeong CHOI
;
Sang Wook LIM
;
Jae Wan PARK
;
Kyung Wha WHANG
;
In Sup ANN
;
Joon Young KIM
;
Jane C OH
;
Pil Won PARK
;
Tae Yong KIM
;
Yoon Kyung CHO
;
Dong Hoon CHA
- Publication Type:Original Article
- Keywords:
Intravenous amiodarone;
Acute myocardial infarction;
Ventricular tachyarrhythmias
- MeSH:
Amiodarone*;
Atrioventricular Block;
Humans;
Hypotension;
Myocardial Infarction*;
Retrospective Studies;
Shock, Cardiogenic;
Tachycardia*
- From:Korean Circulation Journal
1998;28(8):1314-1321
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Recently, the amiodarone has emerged as a promising antiarrhythmic agent and its efficacy and safety has been widely accepted with many literatures. But there was no general agreement regarding the dosage and indication of intravenous (IV) amiodarone in acute myocardial infarction with life-threatening refractory ventricular tachyarrhythmias. METHOD: From October 1995 through October 1997, we recruited retrospectively 9 patients of acute myocardial infarction who had received IV amiodarone for life-threatening refractory ventricular tachyarrhythmias and analyzed the initial response, adverse effect, and loading dose. RESULTS: 1) Acute efficacy:Eight of 9 patients promptly restored normal sinus rhythm immediately after intravenous amiodarone administration. 2) In-Hospital Mortality:One patients died due to ventricular tachyarrhythmias refractory to aggressive management and 5 in 8 patients who had responded promptly with IV amiodarone discharged alive and other 3 patients died due to cardiogenic shock with normal sinus rhythm. 3) Immediate adverse effects:Five patients experienced immediate adverse effects after IV amiodarone; 3 patients of hypotension, 1 patient of first degree AV block, and the other of Morbitz type 2 AV block. 4) Long term follow-up:Among 5 patients discharged alive, one died as unexpected consequence. Other 4 patients have been still alive without maintenance medication. CONCLUSION: The IV amiodarone for suppression of life-threatening ventricular tachyarrhythmias in patients with acute myocardial infarction seemed to be an effective second-line therapeutic drug and have acceptable adverse effects. In the future, the large scale study regarding the dosage and indication might be warrented.
