Association of SCN10A single nucleotide polymorphism rs12632942 and oxaliplatin-induced peripheral neuropathy in colorectal cancer patients receiving chemotherapy
10.3872/j.issn.1007-385x.2019.07.011
- VernacularTitle:SCN10A rs12632942单核苷酸多态性与结直肠癌化疗奥沙利铂外周神 经毒性的相关性
- Author:
KONG Lianguang
1
;
PENG Junling
2
;
ZHENG Xiangzhen
1
;
SU Fang
3
;
WEI Yisheng
4
;
ZHANG Xiao
4
;
HONG Chuyuan
4
;
WENG Jieling
5
Author Information
1. Department of General Surgery, Guangzhou Baiyun District Hospital of Chinese Medicine
2. Department of Molecular Diagnostics, Sun Yat-Sen University Cancer Center
3. .Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
4. Laboratory of Surgery, Department of Gastrointestinal Surgery, the SecondAffiliated Hospital of Guangzhou Medical University
5. Department of Pathology, the SecondAffiliated Hospital of Guangzhou Medical University
- Publication Type:Journal Article
- Keywords:
oxaliplatin;
SCN10A;
single nucleotide polymorphism;
neuropathy;
colorectal cancer
- From:
Chinese Journal of Cancer Biotherapy
2019;26(7):788-792
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the association between single nucleotide polymorphism rs12632942 in SCN10A exon and oxaliplatin-induced peripheral neuropathy (OXLIPN) in colorectal cancer (CRC) patients receiving chemotherapy. Methods:Atotal of 319 cases of blood samples from CRC patients receiving chemotherapy regimen with Oxaliplatin (OXL) were collected from the Second Affiliated Hospital of Guangzhou Medical University, the Second Affiliated Hospital of Nanchang University, and Guangzhou Baiyun District Hospital of Chinese Medicine during January 2011 and June 2013. DNAwas routinely extracted, and PCR amplification was performed to analyze the genotype of rs12632942; and OXLIPN of patients was also evaluated. The association between rs12632942 genotype and OXLIPN was analyzed by χ2 test and multivariate logistic regression model. Results: The genotypes of rs12632942 of 319 CRC patients:AAof 134 cases,AG of 156 cases and GG of 29 cases; and the genotype distribution of rs12632942 was in accordance with Hardy-Weinberg equiliberum (P>0.05). χ2 test showed that rs12632942AG+GG genotype was associated with Ⅱ-Ⅳ degree OXLIPN (P<0.01). Multivariate logistic regression model showed that rs12632942 AG + GG genotype was an independent risk factor for Ⅱ-Ⅳ degree OXLIPN（OR=2.044； 95%CI=1.231-3.392; P<0.01） . Conclusion: Colorectal cancer patients with SCN10A exon polymorphism rs12632942AG + GG genotype were susceptible to Ⅱ-Ⅳ degree OXLIPN.
- Full text:20190711.pdf
